Results 51 to 60 of about 147,729 (282)

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Mitochondrial Donation — Ethical Considerations

Fertility & Reproduction, 2022
Background: Mitochondrial donation is an assisted reproductive technology that can be used to avoid transmission of mitochondrially encoded mitochondrial DNA disease from women to their children. The Australian government is currently considering whether
Ainsley NEWSON
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

A mental health intervention program for the oocyte donors: protocol for a mixed methods study

Reproductive Health, 2020
Background Oocyte donation is one of the assisted reproductive techniques that can undermine the mental health of the women donor. As such, the aim of this study is to design a mental health promotion program for oocyte donors.
Elham Adib Moghaddam, Ashraf Kazemi, Gholamreza Kheirabadi, Seyyed Mehdi Ahmadi   +3 more
doaj   +1 more source

Oocyte Donation [PDF]

Deutsches Ärzteblatt international, 2011
In 2008 and 2009, the authors saw in their institution three women who had undergone oocyte donation and went on to develop severe de novo hypertension before the 26(th) week of gestation, with values above 180/110 mm Hg. Pregnancy was prematurely terminated in these cases because of the acute threat to the mother's life, and none of the three neonates
Ulrich, Pecks, Nicolai, Maass, Joseph, Neulen   +2 more
openaire   +2 more sources

A descriptive study of selected oocyte, blood and organ/tissue donation features among fertility patients in Ireland.

, 2010
OBJECTIVE: Anonymous oocyte donation and participation in organ and blood/tissue donation programmes were studied specifically among Irish fertility patients.
Ahmed B. Omar, Omar, A.B., Walsh, D.J., Walsh, DJ, Walsh, Anthony P.H., Collins, Gary, Umme Salma, Collins, G.S., Walsh, David J., Collins, GS, Omar, AB, David J. Walsh, Collins, Gary S.; id_orcid, Salma, Umme, Anthony P. H. Walsh, Gary S. Collins, Omar, Ahmed B., Walsh, A.P.H., Salma, U., Sills, E. Scott, Sills, E.S., Salma, U, Walsh, AP, E. Scott Sills, Sills, ES   +24 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

When are bereaved family members approached for consent to organ donation? Commentary from 10 European member states [PDF]

, 2014
Background - To scope the timing of the approach to bereaved family members and request for organ donation in DBD and DCD potential donors, in 10 European member states. Are there changes in established practice regarding when family members are asked to
Long-Sutehall, Tracy, Jansen, Nichon, Sque, Magi, McDonald, Maryon, Haase-Kromwijk, Bernadette   +4 more
core   +2 more sources

Implications of oocyte cryostorage for the practice of oocyte donation [PDF]

Human Reproduction, 2012
As the efficiency of oocyte cryopreservation has increased rapidly in recent years, oocytes are currently being stored either in the course of IVF treatments or as a fertility preservation measure. These practices may have an impact on the number of available donor oocytes due to two different dynamics: first, a certain percentage of women for whom ...
Heidi, Mertes, Guido, Pennings, Wybo, Dondorp, Guido, de Wert   +3 more
openaire   +2 more sources

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source