Results 211 to 220 of about 176,418 (306)

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

A human CEP120 gene variant impairs meiotic spindle building causing aneuploidy†. [PDF]

Biol Reprod
Duke M, Blengini CS, Maddocks S, Aboelenain M, Prorock-Rogers C, Schindler K.   +5 more
europepmc   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Use of Autologous Exosomes to Enhance Oocyte Maturation in Patients with Diminished Ovarian Reserve: A Prospective, Randomized Clinical Trial (Pilot Study). [PDF]

Bioengineering (Basel)
Navarro Arrieta CT, Zavos PM, Aragona C, Saleem SAMA, Bezerra Espinola MS, Navarro VA.   +5 more
europepmc   +1 more source

Improving ARTs: Microfluidics as a Tool for Sperm Selection

Andrology, EarlyView.
ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez, A. Urriés, J. L. de Pablo, L. Serrano‐Ramón, S. Sanchez, R. Herrer, J. M. Morrell, C. Malo   +7 more
wiley   +1 more source

Efficacy of follitropin delta in potential low responders: a pooled analysis of individual patient data from five randomized controlled trials. [PDF]

Front Endocrinol (Lausanne)
Lobo R, Falahati A, Jepsen IE, Polyzos NP, García-Velasco JA, Pinborg A, Gravotta E.   +6 more
europepmc   +1 more source

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Curcumin-Loaded Milk-Derived Exosomes Improve the Developmental Competence of Yak Oocytes by Regulating Mitophagy. [PDF]

Antioxidants (Basel)
Lu T, Ma X, Wang M, Pan Y, Yang X, Qiu S, Yang X, Yu S.   +7 more
europepmc   +1 more source

Sperm Selection Using Micro Swim‐Up: Improvement of Chromatin Integrity Compared to Density Gradient Centrifugation

Andrology, EarlyView.
ABSTRACT Background Selecting high‐quality spermatozoa with optimal nuclear integrity is a crucial step in assisted reproductive technologies (ART). While density gradient centrifugation (DGC) is widely used, the associated centrifugation steps may induce cell stress, potentially damaging sperm DNA.
Simone Palini, Serena Benedetti, Silvia De Stefani, Luca Galluzzi, Mariangela Primiterra, Sara Rita D'Errico, Michele Tanturli, Monica Muratori   +7 more
wiley   +1 more source