Andrology, EarlyView.ABSTRACT Background Macrozoospermia is a rare form of teratozoospermia characterized by tetraploids, large‐headed spermatozoa with multiple flagella, usually caused by bi‐allelic AURKC mutations. The etiology of atypical phenotypes with a lower proportion of large headed spermatozoa and single flagella however often remains unresolved.
Aurore Perrin +14 more
wiley +1 more source
Determinants of clinical pregnancy outcomes in women with diminished ovarian reserve undergoing repeated assisted reproductive technology cycles: a retrospective cohort analysis of 3,895 oocyte retrieval cycles. [PDF]
Front Endocrinol (Lausanne)Zhang X +7 more
europepmc +1 more source
The Embryonic Development of the Cotylean Polyclad Phrikoceros jannetae
Acta Zoologica, EarlyView.ABSTRACT Polyclads exhibit distinct developmental modes ranging from direct to indirect development, with several transitional stages also recognised. The existence of an indirect developmental mode in polyclads with a planktonic life history stage in the form of a free‐swimming larva is unique among all free‐living flatworms and makes polyclads a ...
Mehrez Gammoudi +6 more
wiley +1 more source
Vitrification altered αV and β3 integrin expression in mouse oocytes in a maturation stage-dependent manner. [PDF]
Mol Biol RepAndi S, Rajaei F, Darabi S.
europepmc +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Ovaries of Three Eukerria and Two Kerriona Earthworms (Annelida, Crassiclitellata, Ocnerodrilidae) Are Morphologically Different, but Their Microorganization and Oogenesis Are the Same. [PDF]
J MorpholŚwiątek P +4 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
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Loss of Nemp1 disrupts female meiosis and activates a conserved ATM-CHK2 checkpoint. [PDF]
Nat CommunHakim BA +14 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Differential regulation of ribogenesis genes throughout oogenesis in thicklip grey mullets, Chelon labrosus, preparing the maternal contribution to embryo development. [PDF]
PLoS OneBir J +3 more
europepmc +1 more source