Results 241 to 250 of about 176,418 (306)

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu   +20 more
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh   +4 more
wiley   +1 more source

RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation. [PDF]

open access: yesLife Sci Alliance
Sun Z   +8 more
europepmc   +1 more source

Human OTOP3 requires strong acidification for activation and exhibits mixed proton-anion permeation. [PDF]

open access: yesJ Biol Chem
Morais TDC   +7 more
europepmc   +1 more source

Molecular and developmental consequences of heat stress on the bovine oocyte and embryo competence. [PDF]

open access: yesAnim Reprod
Ramírez GG   +7 more
europepmc   +1 more source

Fertilization time and oocyte spindle integrity: implication for embryo ploidy. [PDF]

open access: yesReprod Fertil
Kratochvilova I   +8 more
europepmc   +1 more source

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