Results 271 to 280 of about 298,840 (357)

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Establishment of a Single-Oocyte Culture System for Pigs and Its Validation Using Curcumin as a Model Antioxidant for Oocyte Maturation. [PDF]

Animals (Basel)
Namula Z, Otoi T, Tharasanit T, Chatdarong K, Nagahara M, Widodo OS, Nakai A, Nguyen ST, Nakayama Y, Hirata M, Tanihara F.   +10 more
europepmc   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Administration of ethiodized poppy seed oil-based contrast agent into the uterus enhances fertilization rate in mice inseminated with low sperm numbers. [PDF]

Hum Reprod
Del Llano E, Rasschaert M, Arnoult C, Robert P, Ray PF, Loeuillet C.   +5 more
europepmc   +1 more source

Revisiting Maturity Data: Using Oocyte Diameter and Gonadosomatic Index to Retroactively Apply a New Maturity Scale to Greenland Halibut (Reinhardtius hippoglossoides)

Fisheries Management and Ecology, EarlyView.
ABSTRACT Greenland halibut (Reinhardtius hippoglossoides) is a deep‐water flatfish which lives at temperatures of 1°C–4°C and produces large eggs (> 3 mm). The combination of low temperatures and large eggs has resulted in an unusual ovary development cycle, with vitellogenesis taking more than 1 year.
James Kennedy, Ásgeir Gunnarsson, Svanhildur Egilsdóttir, Bjarki Þór Elvarsson   +3 more
wiley   +1 more source

Options for Final Oocyte Maturation Trigger: Can the Ovarian Response Prediction Index (ORPI) Guide the Optimal Choice? [PDF]

JBRA Assist Reprod
Franco Junior JG, Petersen CG, Meziara JB, Oliveira JBA.   +3 more
europepmc   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging. [PDF]

Cell Mol Biol Lett
Zhang S, Guo B, Fang J, Wang S, Liu Y, Wu D, Kang N, Zhang Y, Zhen X, Yan G, Ding L, Sun H, Liu C.   +12 more
europepmc   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis. [PDF]

PLoS Genet
Xie Q, Wu H, Qiu J, Liu J, Jiang X, Wu H, Lyu Q, Long H, Li W, Zhang S, Zhou Y, Gao Y, Hsueh AJW, Kuang Y, Suo L.   +14 more
europepmc   +1 more source