Results 121 to 130 of about 16,336,802 (316)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine

JAMA Network Open
ImportancePlacebo effects contribute substantially to the therapeutic success of many treatments, particularly in pain-related conditions. Open-label placebos (OLPs) offer an ethically acceptable approach to harness this potential without deception.ObjectiveTo evaluate the efficacy of a 3-month OLP regimen in reducing headache and migraine days and ...
Julian, Kleine-Borgmann, Katharina, Schmidt, Linda, Ludwig, Moritz, Schulz, Dagny, Holle-Lee, Charly, Gaul, Ulrike, Bingel   +6 more
openaire   +4 more sources

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

Arthritis Research & Therapy, 2019
Background To determine the effect of riociguat, an oral, selective soluble guanylate cyclase stimulator, on the net digital ulcer (DU) burden in systemic sclerosis (SSc).
Vivek Nagaraja, Cathie Spino, Erica Bush, Pei-Suen Tsou, Robyn T. Domsic, Robert Lafyatis, Tracy Frech, Jessica K. Gordon, Virginia D. Steen, Dinesh Khanna   +9 more
doaj   +1 more source

Open-label placebo clinical trials: is it the rationale, the interaction or the pill?

BMJ evidence-based medicine, 2019
National surveys of primary care physicians demonstrate that placebo use is prevalent. Against their widespread use, until recently, it was assumed among researchers that placebos must be deceptively prescribed for beneficial effects to be elicited ...
C. Blease, Michael H. Bernstein, C. Locher   +2 more
semanticscholar   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

An Interpretable, Data‐Driven, Hierarchical Multi‐Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability

Advanced Science, EarlyView.
An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie, Datao Xu, Zhifeng Zhou, Bas Van Hooren, Huiyu Zhou, Yi Yuan, Xiangli Gao, Monèm Jemni, Liangliang Xiang, Meizi Wang, Justin Fernandez, Tibor J. Goda, Yaodong Gu   +12 more
wiley   +1 more source

Long-term follow up of opicapone as add-on to levodopa in Parkinson's patients without motor fluctuations

Journal of Parkinson’s Disease
Primary results from the 24-week EPSILON study (NCT04978597) showed that adding opicapone to levodopa in non-fluctuating Parkinson's patients significantly improved motor impairment without increasing the development of motor complications versus placebo.
Joaquim J. Ferreira, Olivier Rascol, Fabrizio Stocchi, Angelo Antonini, Joana Moreira, Miguel M. Fonseca, José-Francisco Rocha, Helena C. Brigas, Joerg Holenz, Werner Poewe,   +10 more
doaj   +1 more source