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Preoperative Anxiolysis and Treatment Expectation (PATE Trial): open-label placebo treatment to reduce preoperative anxiety in female patients undergoing gynecological laparoscopic surgery - study protocol for a bicentric, prospective, randomized-controlled trial. [PDF]
Front PsychiatryWessels J +6 more
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Choice over placebo administration enhances open-label placebo hypoalgesia
Pain, 2023Abstract Many studies indicate that deceptively administered placebos can improve pain outcomes. However, the deception involved presents an ethical barrier to translation because it violates informed consent and patient autonomy. Open-label placebos (OLPs), inert treatments that are openly administered as placebos, have been proposed as an ...
Biya Tang, Evan Livesey, Ben Colagiuri
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Journal of Integrative and Complementary Medicine, 2022
Objective: An open-label placebo (OLP) is a placebo treatment in which the patient is aware that the treatment is a placebo. OLPs are considered effective for reducing pain, and previous studies have shown a stronger placebo effect for placebo acupuncture than for placebo pills.
Seoyoung Lee +4 more
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Objective: An open-label placebo (OLP) is a placebo treatment in which the patient is aware that the treatment is a placebo. OLPs are considered effective for reducing pain, and previous studies have shown a stronger placebo effect for placebo acupuncture than for placebo pills.
Seoyoung Lee +4 more
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Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy
2023Abstract In recent years, placebos have undergone a rapid development from methodological chaff to therapeutic wheat. Hereby, the role of placebos as a deceptive control in clinical trials, as well as negative denomination for anything murky, changed to an innovative promise, an effective as well as ethical treatment.
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More than consent for ethical open-label placebo research
Journal of Medical Ethics, 2020Recent studies have explored the effectiveness of open-label placebos (OLPs) for a variety of conditions, including chronic pain, cancer-related fatigue and irritable bowel syndrome. OLPs are thought to sidestep traditional ethical worries about placebos because they do not involve deception: with an OLP, patients or subjects are told outright that ...
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Deceptive but not open label placebos attenuate motion-induced nausea
Journal of Psychosomatic Research, 2019Nausea is a common complaint, known to respond to the placebo effect. Existing research has employed deception when administering placebos for nausea, limiting therapeutic translation on ethical grounds. We therefore examined the potential of non-deceptive open-label placebos (OLPs) to reduce nausea.Galvanic Vestibular Stimulation (GVS) and Virtual ...
K, Barnes +3 more
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Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone
Pain, 2022Abstract Open-label placebos, or placebos without deception, have been found to induce analgesia, a challenging concept that need to be investigated in detail. In particular, what we need to know is the mechanism through which analgesia is induced when no deception is involved. In this study, we show for the first time that open-label placebo
Benedetti F. +3 more
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Open-Label Placebo: Reflections on a Research Agenda
Perspectives in Biology and Medicine, 2018Open-label placebos (OLP)-placebo pills honestly prescribed-have challenged the notion that placebos require either deception or concealment to evoke salubrious benefits. This essay describes how the author arrived at the counter-intuitive OLP hypothesis, discusses evidence for OLP effectiveness, and examines mechanistic explanations for OLP.
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Open-label placebo reduces fatigue in cancer survivors: a randomized trial
Supportive Care in Cancer, 2018Cancer-related fatigue (CRF) is a common and challenging late effect for many cancer survivors. Clinical trials demonstrate robust placebo effects on CRF in blinded trials. Recently, open-label placebo (OLP) has been shown to improve a variety of symptoms in other populations.
Eric S. Zhou +5 more
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A Fictionalist Account of Open-Label Placebo
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of MedicineAbstract The placebo effect is now generally defined widely as an individual’s response to the psychosocial context of a clinical treatment, as distinct from the treatment’s characteristic physiological effects. Some researchers, however, argue that such a wide definition leads to confusion and misleading implications.
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