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Open-label nondeceptive placebos
Open-label placebos (OLPs), where patients are informed they are receiving a placebo, challenge the traditional notion that placebos require deception to be effective. Recent research has shown that OLPs can positively impact subjective outcomes, such as pain perception and symptom severity, across various conditions like chronic pain, mental disorders,Julian, Kleine-Borgmann, Ulrike, Bingel
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Open‐label use of placebos in the treatment of ADHD: a pilot study
Child: Care, Health and Development, 2007AbstractBackground This study examined short‐term efficacy, side effects and acceptability of a placebo treatment procedure designed to maintain children with attention deficit hyperactivity disorder (ADHD) on 50% of their usual stimulant dose.Methods An open‐label prospective crossover trial was conducted in 26 children with ADHD, ages 7–15 years ...
A D, Sandler, J W, Bodfish
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More than consent for ethical open-label placebo research
Journal of Medical Ethics, 2020Recent studies have explored the effectiveness of open-label placebos (OLPs) for a variety of conditions, including chronic pain, cancer-related fatigue and irritable bowel syndrome. OLPs are thought to sidestep traditional ethical worries about placebos because they do not involve deception: with an OLP, patients or subjects are told outright that ...
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Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone
Pain, 2022Abstract Open-label placebos, or placebos without deception, have been found to induce analgesia, a challenging concept that need to be investigated in detail. In particular, what we need to know is the mechanism through which analgesia is induced when no deception is involved. In this study, we show for the first time that open-label placebo
Fabrizio Benedetti +3 more
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European Journal of Applied Physiology, 2019
Recent evidence suggests that deception may not be necessary for placebos to improve clinical outcomes. We tested the hypothesis that placebo and open-label placebo (OLP) treatments would acutely improve strength and voluntary activation, as well as minimize neuromuscular fatigue, in untrained participants.Twenty-one males (n = 11) and females (n = 10)
Alina P. Swafford +5 more
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Recent evidence suggests that deception may not be necessary for placebos to improve clinical outcomes. We tested the hypothesis that placebo and open-label placebo (OLP) treatments would acutely improve strength and voluntary activation, as well as minimize neuromuscular fatigue, in untrained participants.Twenty-one males (n = 11) and females (n = 10)
Alina P. Swafford +5 more
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Worth a try – A survey on the general acceptance of open-label placebos
Journal of Psychosomatic Research, 2023Forkmann, Katarina +3 more
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Children's and parents' perspectives on open‐label use of placebos in the treatment of ADHD
Child: Care, Health and Development, 2007AbstractBackground The purpose of this study was to examine the efficacy and acceptability of an open‐label conditioned placebo dose reduction (CPDR) treatment in 70 children with attention deficit hyperactivity disorder (ADHD). This paper focuses on the qualitative data from the study.Methods Following a double‐blind, crossover dose finding ...
A, Sandler, C, Glesne, G, Geller
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Time to reflect on open-label placebos and their value for clinical practice
Pain, 2023Caitlin M.P. Jones +5 more
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No open-label placebo effect in insomnia? Lessons learned from an experimental trial
Journal of Psychosomatic Research, 2022Julia W Haas +2 more
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