Results 221 to 230 of about 156,017 (326)

When a Placebo Is Not a Placebo: Problems and Solutions to the Gold Standard in Psychotherapy Research

Frontiers in Psychology, 2018
Cosima Locher, Jens Gaab, Charlotte Blease, Charlotte Blease   +3 more
doaj   +1 more source

The placebo puzzle: Putting together the pieces [PDF]

, 2004
Steve Stewart-Williams
core   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial [PDF]

Randall J. Bateman, Yan Li, Eric McDade, Jorge J. Llibre‐Guerra, David B. Clifford, Alireza Atri, Susan L. Mills, Anna Santacruz, Guoqiao Wang, Charlene Supnet, Tammie L.S. Benzinger, Brian A. Gordon, Laura Ibáñez, Gregory Klein, Monika Baudler, Rachelle S. Doody, Paul Delmar, Geoffrey A. Kerchner, Tobias Bittner, Jakub Wojtowicz, Azad Bonni, Paulo Fontoura, Carsten Hofmann, Luka Kulic, Jason Hassenstab, Andrew J. Aschenbrenner, Richard J. Perrin, Carlos Cruchaga, Alan E. Renton, Chengjie Xiong, Alison Goate, John C. Morris, David M. Holtzman, B. Joy Snider, Catherine J. Mummery, William S. Brooks, David Wallon, Sarah Berman, Erik D. Roberson, Colin L. Masters, Douglas Galasko, Suman Jayadev, Raquel Sánchez‐Valle, Jérémie Pariente, Justin Kinsella, Christopher H. van Dyck, Serge Gauthier, Ging‐Yuek Robin Hsiung, Mario Masellis, Bruno Dubois, Lawrence S. Honig, Clifford R. Jack, Alisha Daniels, Ricardo Allegri, Jasmeer P. Chhatwal, Gregory S. Day, Nick C. Fox, Edward D. Huey, Takeshi Ikeuchi, Mathias Jucker, Jae‐Hong Lee, Allan I. Levey, Johannes Levin, Francisco Lopera, Jee Hoon Roh, Pedro Rosa‐Neto, Peter R. Schofield, Peter R. Schofield, Dominantly Inherited Alzheimer’s Disease-Trials Unit   +68 more
openalex   +1 more source

Digital Ulcers in Ssc Treated with Oral Treprostinil: A Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Follow-up [PDF]

, 2017
James R. Seibold, Fredrick M. Wigley, Elena Schiopu, Christopher P. Denton, Richard M. Silver, Virginia Steen, Robyn T. Domsic, Thomas A. Medsger, Maureen D. Mayes, Soumya Chatterjee, Leland W.K. Chung, Mary Ellen Csuka, Dinesh Khanna, David H. Collier, Tracy Frech, Jerry A. Molitor, Naomi F. Rothfield, Ariane L. Herrick, Robert W. Simms, Janet Pope, Murray Baron, Vivien Hsu, Stanford L. Peng, Robert Spiera, Barri J. Fessler, Bashar Kahaleh, John Varga, Kevin Laliberte, Michael S. Wade, Kristan Rollins   +29 more
openalex   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Risk of gastrointestinal bleeding by specific SSRIs and SNRIs: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to estimate the risk of gastrointestinal bleeding (GIB) by selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) individual agents. Methods A systematic review was conducted for each unique antidepressant (i.e.
Ainhoa Gomez‐Lumbreras, Abdelrahman G. Tawfik, Guilherme Del Fiol, Kensaku Kawamoto, Thomas Reese, Katy Trinkley, Aubrey Jones, James Mitchell, Daniel C. Malone   +8 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine: A Randomized Clinical Trial.

JAMA Netw Open
Kleine-Borgmann J, Schmidt K, Ludwig L, Schulz M, Holle-Lee D, Gaul C, Bingel U.   +6 more
europepmc   +1 more source

Secondary Prophylaxis of Hepatic Encephalopathy: An Open-Label Randomized Controlled Trial of Lactulose Versus Placebo [PDF]

, 2009
Barjesh Chander Sharma, Praveen Sharma, Amit Agrawal, Shiv Kumar Sarin   +3 more
openalex   +1 more source