Results 41 to 50 of about 151,642 (322)

Open-label placebo treatment of women with premenstrual syndrome: study protocol of a randomised controlled trial

BMJ Open, 2020
IntroductionRecent evidence suggests that for certain clinical conditions, placebos can improve clinical outcomes even without deception. These so-called open-label placebos (OLPs) bear the advantage of a significant lower risk of adverse events and ...
Cosima Locher, Irving Kirsch, Antje Frey Nascimento, Jens Gaab, Joe Kossowsky, Andrea Meyer   +5 more
doaj   +2 more sources

Reducing Emotional Distress with Open-Label Placebos: Assessing the Role of Motor Engagement in Pill Consumption [PDF]

Behavioral Sciences
It has been posited that ingesting a pill constitutes a pivotal action that facilitates the effects of open-label placebos (OLPs: placebos honestly prescribed).
Anne Schienle, Wolfgang Kogler
doaj   +2 more sources

Open-label placebo clinical trials: is it the rationale, the interaction or the pill?

BMJ Evidence-Based Medicine, 2019
National surveys of primary care physicians demonstrate that placebo use is prevalent. Against their widespread use, until recently, it was assumed among researchers that placebos must be deceptively prescribed for beneficial effects to be elicited ...
C. Blease, Michael H Bernstein, Cosima Locher   +2 more
semanticscholar   +5 more sources

The role of patient beliefs in open-label placebo effects.

Health Psychology, 2019
OBJECTIVE Recent research on open-label placebos, or placebos administered without deception or concealment, suggests that they can be effective in a variety of conditions.
Kari A Leibowitz, E. Hardebeck, J. Goyer, Alia J. Crum   +3 more
semanticscholar   +5 more sources

More than consent for ethical open-label placebo research

Journal of Medical Ethics, 2020
Recent studies have explored the effectiveness of open-label placebos (OLPs) for a variety of conditions, including chronic pain, cancer-related fatigue and irritable bowel syndrome. OLPs are thought to sidestep traditional ethical worries about placebos
Laura Specker Sullivan
semanticscholar   +4 more sources

Noble Humbug? Hard and soft laws on clinical placebo use [PDF]

Frontiers in Psychology
Despite the widespread historical and contemporary use of placebos in medicine, legal regulations addressing their administration remain limited in many countries.
Mélina Richard, Mélina Richard, Manuela Ganz, Lena Dominique Hornstein, Bohdan Stehlik, Mélanie Levy, Charlotte R. Blease, Marco Annoni, Bernice S. Elger, Jens Gaab   +9 more
doaj   +2 more sources

Conditioned open-label placebos to facilitate opioid reduction in patients with chronic non-cancer pain: study protocol of a randomised controlled trial [PDF]

BMJ Open
Introduction Chronic non-cancer pain presents a global health problem, with a significant increase in opioid prescriptions over recent decades. However, opioid therapy poses risks of adverse events, overdose and non-medical use.
Cosima Locher, Antje Frey Nascimento, Isabelle Arnet, Roland von Känel, Joram Ronel, Konrad Streitberger, Michael Bernstein, Helen Koechlin, Katja Carratta, Kiara Bodonyi, Daniel Friis, Lukas Bircher, Alfred Josef Roth, Elisabeth Olliges   +13 more
doaj   +2 more sources

Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment

BMJ Open, 2019
Introduction More than 2 million individuals in the USA have an opioid use disorder (OUD). Methadone maintenance treatment is the gold standard of medication-based treatment for OUD, but high-dose methadone is associated with cardiotoxicity and ...
Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca   +15 more
doaj   +2 more sources

Effects of open-label placebos across populations and outcomes: an updated systematic review and meta-analysis of randomized controlled trials [PDF]

Scientific Reports
This work synthesizes and updates findings from previous systematic-reviews and meta-analyses on open-label placebos (OLPs). For the first time, it directly tests whether OLPs differ in effects between clinical and non-clinical samples, and between self ...
Johannes C. Fendel, Carl Tiersch, Paul Sölder, Jens Gaab, Stefan Schmidt   +4 more
doaj   +2 more sources

A systematic qualitative review of ethical issues in open label placebo in published research [PDF]

Scientific Reports
Open-label placebos (OLPs), which are transparently administered inert treatments, have gained increasing attention in the research community. They have the potential to harness placebo effects without deceiving the patient. The purpose of this study was
Mélina Richard, Michael Bernstein, Jens Gaab, Bernice Elger   +3 more
doaj   +2 more sources