Results 61 to 70 of about 151,642 (322)

Open-Label Placebo Interventions With Drinking Water and Their Influence on Perceived Physical and Mental Well-Being

Frontiers in Psychology, 2021
In recent years, the postulation that deception is necessary for placebos to have an effect on pain relief or increased well-being has come into question. Latest studies have shown that an openly administered mock drug works just as well as a deceptively
Marco Rathschlag, Stefanie Klatt, Stefanie Klatt, Stefanie Klatt   +3 more
doaj   +1 more source

Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos [PDF]

, 2012
BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Adams, Alison E.M., Bishop, Felicity L., Kaptchuk, Ted J., Lewith, George   +3 more
core   +5 more sources

Relieving pain using dose-extending placebos [PDF]

, 2016
Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana, DeGrazia, David, Enck, Paul   +2 more
core   +1 more source

If only they knew! A non‐inferiority randomized controlled trial comparing deceptive and open‐label placebo in healthy individuals

European Journal of Pain, 2023
Placebo use is widespread in clinical practice. However, they are most often administered deceptively rather than openly. It is often suggested that open‐label placebos (OLP) are less effective than deceptive placebos (DP).
L. Druart, S. Graham Longsworth, H. Terrisse, C. Locher, C. Blease, C. Rolland, N. Pinsault   +6 more
semanticscholar   +1 more source

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. [PDF]

, 2004
BACKGROUND: An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind,
Close, DR, Edwards, JCW, Emery, P, Filipowicz-Sosnowska, A, Shaw, T, Stevens, RM, Szczepanski, L, Szechinski, J   +7 more
core   +1 more source

Noninvasive vagus nerve stimulation as acute therapy for migraine. The randomized PRESTO study [PDF]

, 2018
Objective: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled ...
Ambrosini, Anna, Barbanti, Piero, De Tommaso, Marina, Dorlas, Stefanie, Geppetti, Pierangelo, Grazzi, Licia, Liebler, Eric, Martelletti, Paolo, Negro, Andrea, Pierangeli, Giulia, Rainero, Innocenzo, Sarchielli, Paola, Tassorelli, Cristina   +12 more
core   +2 more sources

Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial.

JAMA pediatrics, 2022
Importance Although it is widely believed that concealment or deception is required to elicit a placebo response, recent studies with adults suggest that open-label placebo (OLP) (ie, honestly prescribed placebos) can yield significant benefits.
S. Nurko, M. Saps, Joe Kossovsky, S. Zion, C. Di Lorenzo, Karla K. Vaz, Kelsey Hawthorne, Rina Wu, Steven L Ciciora, J. Rosen, T. Kaptchuk, J. Kelley   +11 more
semanticscholar   +1 more source

Effects of placebos without deception compared with no treatment: protocol for a systematic review and meta-analysis [PDF]

, 2015
Placebos have long provided a robust control for evaluating active pharmacological preparations, but frequently demonstrate a variable therapeutic effect when delivered in double-blinded placebo-controlled trials.
Charlesworth, JE, Howick, Jeremy, Kelley, J, Miller, F, Petkovic, G, Roberts, Nia   +5 more
core   +2 more sources

Placebos in primary care? a nominal group study explicating UK GP and patient views of six theoretically plausible models of placebo practice

BMJ Open, 2020
ObjectivesTo better understand which theoretically plausible placebogenic techniques might be acceptable in UK primary care.DesignA qualitative study using nominal group technique and thematic analysis.
Adam W A Geraghty, Mohana Ratnapalan, Beverly Coghlan, Mengxin Tan, Hazel Everitt, George Lewith, Felicity L Bishop   +6 more
doaj   +1 more source

Effects of an open-label placebo intervention on reactions to social exclusion in healthy adults: a randomized controlled trial

Scientific Reports, 2023
Social exclusion, that is being left out by others, can have adverse consequences for individuals’ psychological well-being. Even short-term experiences of social exclusion strongly threaten basic psychological needs and cause so-called social pain ...
Leonie Stumpp, Melissa Jauch, Dilan Sezer, Jens Gaab, Rainer Greifeneder   +4 more
doaj   +1 more source