Results 121 to 130 of about 22,560,789 (293)
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
LUMINOUS ENVIRONMENT AND OCCUPANT’S SATISFACTION AT OPEN-PLAN OFFICE (Case Study: Jawa Pos Office, Grha Pena 4th Floor, Surabaya) [PDF]
, 2009 Open-plan office provides a spacious workspace for a wide range of work-related activities and a lot of chances to rearrange the workstation. In the workspace, a good lighting condition should be provided.
Dinapradipta, Asri, Nurdiah, Esti Asih
core +1 more source
Effect of open-plan office noise on occupant comfort and performance [PDF]
, 2012 This study investigated effects on comfort, symptoms, and office work performance of exposure to office noise. Forty-nine subjects who were employees working in open-plan offices participated in two full-day experiments simulating an ordinary work day ...
Kristiansen, Jesper +3 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Jointing design in open plan office system
, 2005 Most modern offices use open plan office system due to the flexibility of the product. The open plan office system (OPS) can be customized from low screen to high screen and can be installed and dismantled according to the office needs. According to MIDA
Abdul Rahman, Ahmad Rizal +3 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Базы данных. Open Office Base. Oracle
, 2009 Гриф.В предлагаемом практикуме приведены базовые сведения о работе в Open Office Base (версия 2.3), рассмотрены основы работы с сервером баз данных Oracle 9i/10g.
Смагина Е. А. +4 more
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Tax Systems Modernization: Results of Review of IRS' March 7, 2000, Expenditure Plan [PDF]
, 2000 A letter report issued by the General Accounting Office with an abstract that begins "Pursuant to a legislative requirement, GAO reviewed the Internal Revenue Service's (IRS) second Information Technology Investment Account (ITIA) expenditure plan ...
United States. General Accounting Office.
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source