Results 131 to 140 of about 2,099,286 (284)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Effects of the environmental factors in call centre interiors: a case study

Budownictwo i Architektura
Environmental factors in workspaces affect employee productivity and satisfaction, particularly in call centres. One of the most challenging issues in contemporary offices is overcoming the problems of concentration on work, despite adverse effects such
Joanna Jabłońska, Salih Ceylan
doaj   +1 more source

Adjusting to Open-plan Office [PDF]

, 2014
CEM
Duarte, Jorge
core  

Open-plan office density and environmental satisfaction

, 2002
The open-plan office has been popular among design professionals since the late 1960's. This office design tends to produce higher occupant density than is typically found in traditional enclosed offices, a factor that has the potential to influence environmental satisfaction.
Duval, C. L., Charles, K. E., Veitch, J. A.   +2 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Evidence-Based Design: Theoretical and Practical Reflections of an Emerging Approach in Office Architecture [PDF]

, 2009
Evidence-based design is a practice that has emerged only relatively recently, inspired by a growing popularity of evidence-based approaches in other professions such as medicine.
Budgen, Andrew, Lonsdale, Nathan, Penn, Alan, Sailer, Kerstin, Turner, Alasdair   +4 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Spatial Impact of New Housing Trends in the Periphery of Istanbul Metropolitan Area [PDF]

Globalization had a significant effect on socio-economic and spatial changes in Istanbul as the largest city of Turkey following the trends in other cities of the world since the beginning of 1980. In this transformation process which the city center was
Ferhan Gezici, Tuba Inal Cekic
core  

Kajian Daya Dukung Sumber Air Hujan Terhadap Rencana Tata Ruang Wilayah (Rtrw) Kota Depok [PDF]

, 2014
A city development is indicated by population growth and more complete facilities compare to rural area. Depok is one of city with massive development nowadays with high economic potential.
SA’AT, J. (JASURI)
core  

Lighting of open plan (automated) offices

, 1995
ABSTRACT UGHTING OF OPEN PLAN (AUTOMATED) OFFICES İlkin öner M.F.A. in Interior Architecture and Environmental Design Supervisor Assoc. Prof. Dr. Cengiz Yener January, 1995 Lighting in Open Plan (Automated) offices is an important factor for the workers performance and productivity.
openaire   +2 more sources