Results 131 to 140 of about 811,937 (287)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Open-plan office density and environmental satisfaction

, 2002
The open-plan office has been popular among design professionals since the late 1960's. This office design tends to produce higher occupant density than is typically found in traditional enclosed offices, a factor that has the potential to influence environmental satisfaction.
Duval, C. L., Charles, K. E., Veitch, J. A.   +2 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A field study on thermal comfort and adaptive behaviour of university open-plan offices in severe cold regions of China

Journal of Asian Architecture and Building Engineering
This study investigates the thermal comfort and adaptive behaviours of occupants in open-plan office spaces at a university located in Northeast China, a region characterized by severely cold winters with an average temperature ≤−10°C in the coldest ...
Hongrui Zhang, Cheng Sun, Luchen Zhang, Bin Yan, Ying Liu, Qi Dong   +5 more
doaj   +1 more source

Reframing the Work of Rural Community Development: Case Studies in Innovative Rural Business Strategies [PDF]

, 2007
Much of community development work in this country is understood in urban terms - densely populated areas with attendant economies of scale, housing issues that can be addressed largely in isolation of economic development and infrastructure issues ...
Anne Gass, David Dangler, Marcia Nedland
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Lighting of open plan (automated) offices

, 1995
ABSTRACT UGHTING OF OPEN PLAN (AUTOMATED) OFFICES İlkin öner M.F.A. in Interior Architecture and Environmental Design Supervisor Assoc. Prof. Dr. Cengiz Yener January, 1995 Lighting in Open Plan (Automated) offices is an important factor for the workers performance and productivity.
openaire   +2 more sources

Report of the New Court House Commission of the State of Rhode Island [PDF]

, 1924
The Commission appointed to consider the Selection of a Site and the Preparation of Preliminary Plans for a New Court House in the City of ...

core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

\u3cem\u3eBaltimore v. Valsamaki\u3c/em\u3e: The Maryland Court of Appeals\u27 Response to \u3cem\u3eKelo\u3c/em\u3e [PDF]

, 2015
In the years following the Supreme Court’s controversial decision in Kelo v. New London, state judges and legislators across the country responded with a tidal wave of reform to state eminent domain law.
Shaw, Jeff
core   +1 more source