Results 131 to 140 of about 53,666 (300)
Journal of Asian Architecture and Building EngineeringThis study investigates the thermal comfort and adaptive behaviours of occupants in open-plan office spaces at a university located in Northeast China, a region characterized by severely cold winters with an average temperature ≤−10°C in the coldest ...
Hongrui Zhang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Lighting design for open-plan offices
, 2004 Good office lighting is a key element in assuring worker satisfaction and performance. This Update provides guidance on lighting design for open-plan offices based on current best practice and the results of research conducted by NRC's Institute for ...
Veitch, J. A. +3 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Acoustical design for open-plan offices
, 2004 This Update discusses how to achieve acceptable acoustical privacy in open-plan offices. The information is derived from current best practice and the results of research carried out by NRC's Institute for Research in Construction.Ce num\ue9ro traite des
Bradley, J. S.
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, 2021 Markmið rannsóknar var að bera kennsl á helstu áhrifaþætti í opnum eða verkefnamiðuðum vinnurýmum á skynjaða framleiðni eða velferð þekkingarstarfsmanna ásamt því að skilja orsakasamhengi skynjaðrar framleiðni, velferðar og opinna eða verkefnamiðaðra ...
Ragnheiður Hulda Ólafsdóttir 1992-
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source