Results 51 to 60 of about 626,537 (285)

Förderbedingungen für Publikationsfonds: Open Access – ganz oder gar nicht?

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2019
Welche Förderbedingungen für Open-Access-Publikationsfonds sind sinnvoll oder gar notwendig? Sind die damit verbundenen Hürden und Einschränkungen mit dem Ziel einer vollständigen Transformation des wissenschaftlichen Publikationssystems zu Open Access ...
Christof Capellaro, Christian Kaier
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

OA2020: Initiative for the Large-Scale Transformation to Open Access [PDF]

, 2017
Presentation presented by Dr Ralf Schimmer to University of Pretoria staff members in the Merensky 2 auditorium on 10 May 2018.In March 2016, the international initiative Open Access 2020 (OA2020, www.oa2020.org) was launched.
Ralf Schimmer, Schimmer, Ralf
core  

Von Bottom up zu Top down

o-bib. Das offene Bibliotheksjournal, 2019
In den meisten Universitäten sind Dienste rund um das Open-Access-Publizieren inzwischen gut etabliert. Open Educational Resources spielen dagegen in vielen Fällen eine eher untergeordnete Rolle.
Carsten Elsner, Nicole Rosenke, Markus Weber, Christian Hoppe, Stefan Drößler, Sibylle Hermann   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Technikfolgenabschätzung als Perspektive zur Gestaltung der Open-Access-Transformation

o-bib. Das offene Bibliotheksjournal
Der technologische Wandel des wissenschaftlichen Publizierens bringt Ambivalenzen mit sich. Das äußert sich in grundsätzlicher und spezifischer Kritik an Open Access.
Stefan Drößler, Sebastian Flaig, Jonas Scherr   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Open-Access-Transformation komplementär zu DEAL: Forum 13+

o-bib. Das offene Bibliotheksjournal
Der Arbeitskreis Forum 13+ ist ein unabhängiges Gremium von Expertinnen und Experten aus deutschen Bibliothekskonsortien als Akteuren der überregionalen Lizenzierung, von Open-Access-Infrastrukturprojekten, Universitätsbibliotheken, des Deutschen ...
Kristine Hillenkötter, Hildegard Schäffler   +1 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source