Results 111 to 120 of about 1,249,788 (300)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang   +19 more
wiley   +1 more source

The Little White / Black Book of the Ethnological Archive of the Museum of the Romanian Peasant. 2009-2019

open access: yesMartor, 2019
In the last 10 years, the Ethnological Archive of the Museum of the Romanian Peasant has gone through different stages during a period marked, on the one hand, by the settling down of the Museum, and on the other hand, by the passing of the torch from ...
Iris Șerban   +2 more
doaj  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao   +7 more
wiley   +1 more source

Open Clasp, Open Archive: Intimacy and Distance in an Archival Collaboration

open access: yesGlobal Performance Studies, 2021
Chedgzoy K   +3 more
openaire   +2 more sources

Analisi citazionale e indicatori bibliometrici nel modello Open Access [PDF]

open access: yes, 2007
This article is focused on the bibliometric methods used for research evaluation, within the well known field of the bibliometrics which uses mathematical and statistical techniques to analyze the publications distribution patterns, and to explore their ...
De Robbio, Antonella
core  

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

open access: yesAdvanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang   +8 more
wiley   +1 more source

Free and open scholarship in the internet age

open access: yes, 2010
Describes an action research project on scholarly communication in early stages. Research sites include the Open Access Journal Supports in Canada research team, E-LIS, the Open Archive for Library and Information, Scholarly and Research Communication ...
Morrison, Heather
core  

A Perspective on Interactive Theorem Provers in Physics

open access: yesAdvanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement

open access: yesAdvanced Science, EarlyView.
The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang   +7 more
wiley   +1 more source

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