Results 61 to 70 of about 1,136,084 (297)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Publish wisely or perish? an open archive for MarBEF [PDF]

open access: yes, 2005
While scientists are publishing around two million papers annually (Odlyzko, 1998), it is surprising to notice that this growing resource of information is seldom easily accessible, even to those scientists.
Appeltans, Ward   +2 more
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin   +6 more
wiley   +1 more source

The HD(CP)2 Data Archive for Atmospheric Measurement Data

open access: yesISPRS International Journal of Geo-Information, 2016
The archiving of scientific data is a sophisticated mission in nearly all research projects. In this paper, we introduce a new online archive of atmospheric measurement data from the "High definition clouds and precipitation for advancing climate ...
Erasmia Stamnas   +3 more
doaj   +1 more source

Organic Eprints – helping research results go to work [PDF]

open access: yes, 2014
Research results regarding organic food and farming from Europe have become easily accessible – and so can results from the rest of the world. The Open Access archive Organic Eprints (www.orgprints.org) has developed since the start in 2002 so that it ...
Jensen, Allan Leck   +2 more
core   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan   +22 more
wiley   +1 more source

A magyar internet történetei

open access: yesDigitális Bölcsészet, 2022
Márton Németh
doaj   +1 more source

MarBEF publishing revisited [PDF]

open access: yes, 2006
Networking and integration served within a partnership approach and covered with a delicious sauce of free and open access to data and information is MarBEF’s main dish, and it is this recipe that has helped MarBEF to successfully bring marine ...
Appeltans, Ward   +2 more
core   +1 more source

Demystifying Kepler Data: A Primer for Systematic Artifact Mitigation

open access: yes, 2012
The Kepler spacecraft has collected data of high photometric precision and cadence almost continuously since operations began on 2009 May 2. Primarily designed to detect planetary transits and asteroseismological signals from solar-like stars, Kepler has
Barclay, T.   +5 more
core   +1 more source

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