Results 141 to 150 of about 1,208,725 (297)
Библиосфера, 2015 Russian institutional and thematic repositories are analyzed. The general and specific characteristics for systematization and classification of open access repositories are shown: the type (kind) of a repository, type and nature of an institution ...
M. Yu. Rozhdestvenskaya
doaj
, 2019 Aquest treball consisteix en el disseny i desenvolupament d'un arxiu de dades astronòmiques. En el camp astronòmic, instruments connectats a telescopis són els principals productors de dades. Per proporcionar l'accés a la gran quantitat de dades generades, s'utilitzen arxius astronòmics.
openaire +1 more source
Advanced Science, EarlyView.Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan +19 more
wiley +1 more source
Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
SCOPE: A digital archives access interface
Code4Lib Journal, 2019 The Canadian Centre for Architecture (CCA) identified certain technological issues, namely extensive reference workflows and under-utilizing existing metadata, as significant barriers to access for its born-digital archives.
Kelly Stewart, Stefana Breitwieser
doaj
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao +18 more
wiley +1 more source
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
The Open Archives Initiative Object Reuse and Exchange (OAI-ORE)
, 2007 The Open Archives Initiative Object Reuse and Exchange (OAI-ORE) is a new collaborative international initiative, funded for the next 2 years by the Mellon Foundation, focusing on an interoperability framework for the exchange of information about ...
Hunter, Jane
core
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source