Results 41 to 50 of about 603,679 (296)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Apropiación social del conocimiento: Una nueva dimensión de los archivos

Revista Interamericana de Bibliotecología, 2012
Social appropriation of knowledge is a theme of recent concern by scientific communities, governments and mass media and it is assumed as a commitment to the community. This article aims to contribute to the theme from the archives.
Sebastián Alejandro Marín Agudelo
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Open Archive

, 2002
Una presentazione degli Open Archives, e in particolare degli E-prints server, archivi preposti al deposito dei documenti scientifici in forma elettronica, e alla loro gestione e conservazione. Analizza tipologie, soluzioni tecniche e organizzative, principali software disponibili, implicazioni sul piano del diritto d'autore e possibili sviluppi.
openaire   +2 more sources

Developing a model for e-prints and open access journal content in UK further and higher education [PDF]

, 2005
A study carried out for the UK Joint Information Systems Committee examined models for the provision of access to material in institutional and subject-based archives and in open access journals.
Rowland, Fytton, O'Brien, Ann, Oppenheim, Charles, Brown, Sheridan, Swan, Alma, Probets, Steve, Needham, Paul A. S., Hardy, Rachel, Needham, Paul, Muir, Adrienne, O’Brien, Ann   +10 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The subjectivity of archives: Learning from, with, and resisting archives and archival sources in teaching and learning history

Historical Encounters: A Journal of Historical Consciousness, Historical Cultures, and History Education, 2019
In this article, I reflect on my experience managing the development of online archives to argue that the subjectivities of the archives and the sources within them need to be at the forefront of how educators and researchers use archived primary ...
Samantha Cutrara
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Open Archive

Open Archive Management is the application of open source technologies and archivologic biblioteconomic library information science (LIS) to the organization of files in any size and degree of complexity. It was developed through decades working with the World Wide Web Constortium (W3C) which develops the internet standards and the International ...
openaire   +4 more sources