Results 51 to 60 of about 1,103,131 (296)

Direct numerical simulation of open-channel flow over a fully-rough wall at moderate relative submergence [PDF]

, 2017
Direct numerical simulation of open-channel flow over a bed of spheres arranged in a regular pattern has been carried out at bulk Reynolds number and roughness Reynolds number (based on sphere diameter) of approximately 6900 and 120, respectively, for ...
Flack, Hoyas, Marco Mazzuoli, Markus Uhlmann, Nikuradse, Reynolds, Schlichting, Schlichting   +7 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

NUMERICAL ANALYSIS OF OPEN CHANNEL STEADY GRADUALLY VARIED FLOW USING THE SIMPLIFIED SAINT-VENANT EQUATIONS

TASK Quarterly, 2011
For one-dimensional open-channel flow modeling, the energy equation is usually used. There exist numerous approaches using the energy equation for open-channel flow computations, which resulted in the development of several very efficient methods for ...
WOJCIECH ARTICHOWICZ
doaj  

A Laboratory Study on the Design and Performance Evaluation of Pitot-Tube

Journal of Innovative Science and Engineering, 2023
Due to the increasing demand for water resources worldwide, this commodity and its spatial and temporal properties are of the interest for decision makers and scientists. On the other hand, the accuracy in detecting the physical characteristics of the
Yasemin ESKİ, Babak VAHEDDOOST, Damla YILMAZ   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Boundary States of D-branes in AdS_3 Based on Discrete Series [PDF]

, 2001
We study D-branes in the Lorentzian AdS_3 background from the viewpoint of boundary states, emphasizing the role of open-closed duality in string theory. Employing the world sheet with Lorentzian signature, we construct the Cardy states with the discrete
Hikida, Yasuaki, Sugawara, Yuji
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Investigating the Effect of Circular Bridge Piers on Local Scouring at 60° Channel Junctions Using SSIIM1 3D Numerical Model [PDF]

علوم و مهندسی آبیاری, 2018
Insertion of different water structures such as bridge piers in the flow path contracts the flow cross section and causes backwater at upstream sections.
rasool ghobadian, Mahsa Basiri, Zahra Seyedi Tabar   +2 more
doaj   +1 more source