Results 71 to 80 of about 843,782 (345)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A study of unsteady flow wave attenuation in partially filled pipe networks [PDF]
, 1984 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The attenuation of unsteady flow in building drainage systems must be fully considered if water conservation proposals involving changes in flush volume or
Bridge, Sarah
core
Modelling and analysis of open-channel networks [PDF]
, 2022 openNegli ultimi decenni, il riscaldamento globale ha aumentato la frequenza e l'intensità delle precipitazioni, sottoponendo a una forte sollecitazione i sistemi di drenaggio delle aree urbane che non sono progettati per gestire questi fenomeni ...
FRIGO, MICHELE
core
Prediction of depth-averaged velocity in an open channel flow
Applied Water Science, 2018 This paper presents a new methodology to predict the depth-averaged velocity along the lateral direction in an open channel flow. The novelty of this work is to determine the point velocity and estimate the discharge capacity by knowing the geometrical ...
Jnana Ranjan Khuntia +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Dynamics of laminar pressure-driven channel flows laden with neutrally buoyant finite-size particles. [PDF]
, 2013 Since the pioneering work of Reynolds (1883), much effort has been allocated on the topic of laminar-turbulent transition regime in a single-phase flow, with special focusing on the unstable and intermittent natures of this regime (Mullin, 2011).
Loisel, Vincent +3 more
core
Flow separation control in open-channel bends [PDF]
, 2016 © 2015 The Chinese Institute of EngineersThe investigation of fluid flow in sharp open-channel bends is key to controlling undesired sedimentation in natural river reaches.
Akhtari, Ali Akbar, Seyedashraf, Omid
core +1 more source
Jurnal Teknik Mesin--Flow Depth can be defined as channel height or open channel flow depth, is an important parameter in hydraulic calculations and analysis. The depth of flow in the U channel (U channel) of the Student Practice Room (RPS) for Automotive Light Vehicle ...
rdwi pudji susilo
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source