Results 51 to 60 of about 843,782 (345)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Anabranching and maximum flow efficiency in Magela Creek, northern Australia [PDF]
, 2004 Anabranching is the prevailing river pattern found along alluvial tracts of the world's largest rivers. Hydraulic geometry and bed material discharge are compared between single channel and anabranching reaches up to 4 times bank-full discharge in Magela
Nanson, G.C., Jansen, J.D.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Experiments on the effects of heterogeneous roughness in open channel flow [PDF]
, 2007 This project analyses the effects on open channel flow from spatial changes in roughness.Different roughness scenarios are defined in order to have a contrast in velocity to allowfor measurable effects as the roughness distribution changes in the ...
Jarquin, M.F.
core
TASK Quarterly, 2011 For one-dimensional open-channel flow modeling, the energy equation is usually used. There exist numerous approaches using the energy equation for open-channel flow computations, which resulted in the development of several very efficient methods for ...
WOJCIECH ARTICHOWICZ
doaj
A lattice Boltzmann model for the open channel flows described by the Saint-Venant equations [PDF]
Royal Society Open Science, 2019 A new lattice Boltzmann method to simulate open channel flows with complex geometry described by a conservative form of Saint-Venant equations is developed.
Zhonghua Yang, Fengpeng Bai, Ke Xiang
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Simulation of solute transport in Pingjiang karst underground river
Shuiwen dizhi gongcheng dizhiThe flow rate of the Pingjiang Underground River exhibits rapid fluctuations during rainy seasons, yet the variation patterns of solute transport with flow changes remain unclear.
Jiang LIANG +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source