Results 161 to 170 of about 284,682 (289)

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains

, 2012
Recent associations between age-related differentially methylated sites and bivalently marked chromatin domains have implicated a role for these genomic regions in aging and age-related diseases. However, the overlap between such epigenetic modifications
Giulio Disanto, Giovannoni Gavin, Gavin Giovannoni, Ramagopalan Sreeram V., Sandve, GK, Watson Corey T., Ramagopalan, SV, Watson, CT, Sandve Geir Kjetil, Ramagopalan, Sreeram, Sreeram V Ramagopalan, Disanto Giulio, Breden Felix, Corey T Watson, Felix Breden, Breden, F, Giovannoni, G, Geir Kjetil Sandve, Disanto, G   +18 more
core   +1 more source

WhichTF is functionally important in your open chromatin data? [PDF]

PLoS Comput Biol, 2022
Tanigawa Y, Dyer ES, Bejerano G.
europepmc   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression

, 2018
The small ubiquitin-like modifier (SUMO) post-translationally modifies lysine residues of transcription factors and co-regulators and thereby contributes to an important layer of control of the activities of these transcriptional regulators.
Ledsaak, Marit, Eskeland, Ragnhild, Moen, Lisa Marie, Bengtsen, Mads, Rodriguez- Castañeda, Fernando, Gabrielsen, Odd Stokke, Cuervo Torre, Ignacio, Lemma, Roza Berhanu   +7 more
core   +1 more source

Solid-phase capture and profiling of open chromatin by spatial ATAC. [PDF]

Nat Biotechnol, 2023
Llorens-Bobadilla E, Zamboni M, Marklund M, Bhalla N, Chen X, Hartman J, Frisén J, Ståhl PL.   +7 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Allele-Specific Open Chromatin Signals from Heterozygous Lymphoblast Cell Lines.

, 2012
Manhattan plot showing allele-specific signals of open chromatin using the Human CVD beadchip. The BAF of chromosome 11 SNP, rs7120118 (C allele), is significantly enriched following FAIRE-gen, in an examination of 3,129 SNP heterozygous SNPs in 3 ...
Philip Howard (142602), Aroon D. Hingorani (142610), Per Eriksson (27642), Jutta Palmen (142608), Andrew J. P. Smith (142601), Lasse Folkersen (109487), Sonia Shah (142603), Stefan Stender (142604), Meena Kumari (95278), Claudia Giambartolomei (142605), Steve E. Humphries (142616), Anne Tybjærg-Hansen (114875), Philippa J. Talmud (142613)   +12 more
core   +1 more source

Transcriptional and open chromatin analysis of bovine skeletal muscle development by single-cell sequencing. [PDF]

Cell Prolif, 2023
Cai C, Wan P, Wang H, Cai X, Wang J, Chai Z, Wang J, Wang H, Zhang M, Yang N, Wu Z, Zhu J, Yang X, Li Y, Yue B, Dang R, Zhong J.   +16 more
europepmc   +1 more source