Chromatin accessibility: methods, mechanisms, and biological insights
Nucleus, 2022 Access to DNA is a prerequisite to the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and DNA repair. How the proteins that regulate these processes function in the context of chromatin and its
Andrés Mansisidor, Viviana I Risca
exaly +3 more sources
Chromatin accessibility landscape and its association with heterosis in maize hybrids [PDF]
Nature CommunicationsAccessible chromatin regions (ACRs) encompass diverse cis-regulatory elements (CREs) crucial for gene regulation, but their variations from parents to hybrids and their contribution to heterosis remain poorly understood.
Yumin Huang +12 more
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Heparanase Modulates Chromatin Accessibility
Cells, 2023 Heparanase is the sole endoglucuronidase that degrades heparan sulfate in the cell surface and extracellular matrix (ECM). Several studies have reported the localization of heparanase in the cell nucleus, but the functional role of the nuclear enzyme is ...
Honglian Li +7 more
doaj +1 more source
Genome-Wide Association between Transcription Factor Expression and Chromatin Accessibility Reveals Regulators of Chromatin Accessibility. [PDF]
PLoS Computational Biology, 2017 To better understand genome regulation, it is important to uncover the role of transcription factors in the process of chromatin structure establishment and maintenance.
David Lamparter +4 more
doaj +1 more source
Spatially mapped single-cell chromatin accessibility
Nature Communications, 2021 Spatial orientation of cells in an interconnected network is lost in high-throughput single-cell epigenomic assays. Here the authors present sciMAP-ATAC to produce spatially resolved single-cell ATAC-seq data.
Casey A. Thornton +12 more
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Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation
Frontiers in Cell and Developmental Biology, 2021 Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang +11 more
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Evolution and genetic architecture of chromatin accessibility and function in yeast. [PDF]
PLoS Genetics, 2014 Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed ...
Caitlin F Connelly +2 more
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SeATAC: a tool for exploring the chromatin landscape and the role of pioneer factors
Genome Biology, 2023 Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) reveals chromatin accessibility across the genome. Currently, no method specifically detects differential chromatin accessibility.
Wuming Gong +2 more
doaj +1 more source
Profiling single-cell chromatin accessibility in plants
STAR Protocols, 2021 Summary: Coupling assay for transposase-accessible chromatin sequencing (ATAC-seq) with microfluidic separation and cellular barcoding has emerged as a powerful approach to investigate chromatin accessibility of individual cells.
Alexandre P. Marand +4 more
doaj +1 more source
Profiling Chromatin Accessibility at Single-cell Resolution
Genomics, Proteomics & Bioinformatics, 2021 How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity, and enable complex fate decisions are important open questions.
Sarthak Sinha +8 more
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