Results 41 to 50 of about 68,994 (256)

Global chromatin accessibility profiling analysis reveals a chronic activation state in aged muscle stem cells

iScience, 2022
Summary: Regulation of chromatin accessibility is critical for cell fate decisions. Chromatin structure responds to extrinsic environments rapidly. The traditional adult stem cell isolation approach requires tissue dissociation, which triggers stem cell ...
Anqi Dong, Jing Liu, Kangning Lin, Wenshu Zeng, Wai-Kin So, Shenyuan Hu, Tom H. Cheung   +6 more
doaj   +1 more source

Genome-wide chromatin accessibility is restricted by ANP32E [PDF]

Nature Communications, 2020
Abstract Genome-wide chromatin state underlies gene expression potential and cellular function. Epigenetic features and nucleosome positioning contribute to the accessibility of DNA, but widespread regulators of chromatin state are largely unknown.
Kristin E. Murphy, Fanju W. Meng, Claire E. Makowski, Patrick J. Murphy   +3 more
openaire   +3 more sources

Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer

Cell Reports, 2016
Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown.
Nicholas C. Gomez, Austin J. Hepperla, Raluca Dumitru, Jeremy M. Simon, Fang Fang, Ian J. Davis   +5 more
doaj   +1 more source

The accessible chromatin landscape of the human genome [PDF]

Nature, 2012
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue ...
Robert E, Thurman, Eric, Rynes, Richard, Humbert, Jeff, Vierstra, Matthew T, Maurano, Eric, Haugen, Nathan C, Sheffield, Andrew B, Stergachis, Hao, Wang, Benjamin, Vernot, Kavita, Garg, Sam, John, Richard, Sandstrom, Daniel, Bates, Lisa, Boatman, Theresa K, Canfield, Morgan, Diegel, Douglas, Dunn, Abigail K, Ebersol, Tristan, Frum, Erika, Giste, Audra K, Johnson, Ericka M, Johnson, Tanya, Kutyavin, Bryan, Lajoie, Bum-Kyu, Lee, Kristen, Lee, Darin, London, Dimitra, Lotakis, Shane, Neph, Fidencio, Neri, Eric D, Nguyen, Hongzhu, Qu, Alex P, Reynolds, Vaughn, Roach, Alexias, Safi, Minerva E, Sanchez, Amartya, Sanyal, Anthony, Shafer, Jeremy M, Simon, Lingyun, Song, Shinny, Vong, Molly, Weaver, Yongqi, Yan, Zhancheng, Zhang, Zhuzhu, Zhang, Boris, Lenhard, Muneesh, Tewari, Michael O, Dorschner, R Scott, Hansen, Patrick A, Navas, George, Stamatoyannopoulos, Vishwanath R, Iyer, Jason D, Lieb, Shamil R, Sunyaev, Joshua M, Akey, Peter J, Sabo, Rajinder, Kaul, Terrence S, Furey, Job, Dekker, Gregory E, Crawford, John A, Stamatoyannopoulos   +61 more
openaire   +4 more sources

PlantCADB: A comprehensive plant chromatin accessibility database

Genomics, Proteomics & Bioinformatics, 2022
Abstract Chromatin accessibility landscapes are essential for detecting regulatory elements, illustrating the corresponding regulatory networks, and, ultimately, understanding the molecular bases underlying key biological processes.
Ke Ding, Shanwen Sun, Yang Luo, Chaoyue Long, Jingwen Zhai, Yixiao Zhai, Guohua Wang 0001   +6 more
openaire   +2 more sources

Selection on Accessible Chromatin Regions inCapsella grandiflora [PDF]

Molecular Biology and Evolution, 2021
AbstractAccurate estimates of genome-wide rates and fitness effects of new mutations are essential for an improved understanding of molecular evolutionary processes. Although eukaryotic genomes generally contain a large noncoding fraction, functional noncoding regions and fitness effects of mutations in such regions are still incompletely characterized.
Robert Horvath, Emily B Josephs, Edouard Pesquet, John R Stinchcombe, Stephen I Wright, Douglas Scofield, Tanja Slotte   +6 more
openaire   +5 more sources

Mass Spectrometry to Study Chromatin Compaction

Biology, 2020
Chromatin accessibility is a major regulator of gene expression. Histone writers/erasers have a critical role in chromatin compaction, as they “flag” chromatin regions by catalyzing/removing covalent post-translational modifications on histone proteins ...
Stephanie Stransky, Jennifer Aguilan, Jake Lachowicz, Carlos Madrid-Aliste, Edward Nieves, Simone Sidoli   +5 more
doaj   +1 more source

The Mycoplasma hyorhinis genome displays differential chromatin accessibility

Heliyon, 2023
Whilst the regulation of chromatin accessibility and its effect on gene expression have been well studied in eukaryotic species, the role of chromatin dynamics and 3D organisation in genome reduced bacteria remains poorly understood [1,2].
Lewis Taylor, Steven Walsh, Anna Ashton, Norbert Varga, Sejal Kapoor, Charlotte George, Aarti Jagannath   +6 more
doaj   +1 more source

The role of chromatin accessibility in cis-regulatory evolution [PDF]

Genome Biology and Evolution, 2018
ABSTRACT Transcription factor (TF) binding is determined by sequence as well as chromatin accessibility. While the role of accessibility in shaping TF-binding landscapes is well recorded, its role in evolutionary divergence of TF binding, which in turn can alter cis-regulatory activities, is not well understood.
Peng, Pei-Chen, Khoueiry, Pierre, Girardot, Charles, Reddington, James P., Garfield, David A., Furlong, Eileen E.M., Sinha, Saurabh   +6 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source