Results 51 to 60 of about 68,994 (256)

CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo

eLife, 2018
During development eukaryotic gene expression is coordinated by dynamic changes in chromatin structure. Measurements of accessible chromatin are used extensively to identify genomic regulatory elements.
Gabriel N Aughey, Alicia Estacio Gomez, Jamie Thomson, Hang Yin, Tony D Southall   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection.

PLoS Pathogens, 2020
DNA viruses can hijack and manipulate the host chromatin state to facilitate their infection. Multiple lines of evidences reveal that DNA virus infection results in the host chromatin relocation, yet there is little known about the effects of viral ...
Xiangshuo Kong, Guisheng Wei, Nan Chen, Shudi Zhao, Yunwang Shen, Jianjia Zhang, Yang Li, Xiaoqun Zeng, Xiaofeng Wu   +8 more
doaj   +1 more source

Chromatin accessibility: methods, mechanisms, and biological insights

Nucleus, 2022
Access to DNA is a prerequisite to the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and DNA repair. How the proteins that regulate these processes function in the context of chromatin and its
Andrés R. Mansisidor, Viviana I. Risca
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples

Frontiers in Genetics, 2020
While our understanding of cellular and molecular processes has grown exponentially, issues related to the cell microenvironment and cellular heterogeneity have sparked a new debate concerning the cell identity.
Huamei Li, Amit Sharma, Kun Luo, Zhaohui S. Qin, Xiao Sun, Hongde Liu   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nature of the Accessible Chromatin at a Glucocorticoid-Responsive Enhancer [PDF]

Molecular and Cellular Biology, 2004
To gain a better understanding of the nature of active chromatin in mammals, we have characterized in living cells the various chromatin modification events triggered by the glucocorticoid receptor (GR) at the rat tyrosine aminotransferase gene. GR promotes a local remodeling at a glucocorticoid-responsive unit (GRU) located 2.5 kb upstream of the ...
FLAVIN M, CAPPABIANCA, LUCIA ANNAMARIA, KRESS C, THOMASSIN H, GRANGE T.   +4 more
openaire   +3 more sources

Quantitative single-cell imaging suggests increased global chromatin accessibility in tumor versus non-tumor cell lines

iScience
Summary: Cancer phenotypic plasticity is associated with poor prognosis. The mechanisms of phenotypic plasticity are not fully understood. Possibly, the degree of chromatin accessibility defines the easiness of cell transitions between phenotypes.
Mairead Commane, Vidula Jadhav, Katerina Leonova, Brian Buckley, Henry Withers, Katerina Gurova   +5 more
doaj   +1 more source

Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia

Nature Communications, 2023
For around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patients, the molecular mechanism of relapse remains unclear. To fill this gap in knowledge, here we characterize the chromatin accessibility landscape in pediatric relapsed ...
Han Wang, Huiying Sun, Bilin Liang, Fang Zhang, Fan Yang, Bowen Cui, Lixia Ding, Xiang Wang, Ronghua Wang, Jiaoyang Cai, Yanjing Tang, Jianan Rao, Wenting Hu, Shuang Zhao, Wenyan Wu, Xiaoxiao Chen, Kefei Wu, Junchen Lai, Yangyang Xie, Benshang Li, Jingyan Tang, Shuhong Shen, Yu Liu   +22 more
doaj   +1 more source