Results 31 to 40 of about 68,994 (256)
Chromatin accessibility profiling in Neurospora crassa reveals molecular features associated with accessible and inaccessible chromatin [PDF]
BMC Genomics, 2021 Abstract Background Regulation of chromatin accessibility and transcription are tightly coordinated processes. Studies in yeast and higher eukaryotes have described accessible chromatin regions, but little work has been done in filamentous fungi.
Aileen R. Ferraro +5 more
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Epigenetics & Chromatin, 2020 Background Chromatin dysregulation is associated with developmental disorders and cancer. Numerous methods for measuring genome-wide chromatin accessibility have been developed in the genomic era to interrogate the function of chromatin regulators.
Jake J. Reske +2 more
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Butterfly eyespots exhibit unique patterns of open chromatin [version 1; peer review: 2 approved]
F1000Research, 2023 Background: How the precise spatial regulation of genes is correlated with spatial variation in chromatin accessibilities is not yet clear. Previous studies that analysed chromatin from homogenates of whole-body parts of insects found little variation in
Suriya Narayanan Murugesan +1 more
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Cancer chromatin accessed [PDF]
Nature Reviews Genetics, 2018 A study in Science reports the genome-wide chromatin accessibility profiles across 23 cancer types from The Cancer Genome Atlas and notably increases the number of known gene regulatory elements.
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Journal of Integrative Agriculture, 2023 Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly ...
Si-di XIE +8 more
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Histone acetylation increases chromatin accessibility [PDF]
Journal of Cell Science, 2005 In eukaryotes, the interaction of DNA with proteins and supramolecular complexes involved in gene expression is controlled by the dynamic organization of chromatin inasmuch as it defines the DNA accessibility. Here, the nuclear distribution of microinjected fluorescein-labeled dextrans of 42 kDa to 2.5 MDa molecular mass was used to characterize the ...
Görisch, Sabine M. +4 more
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Blocking by Histones of Accessibility to DNA in Chromatin [PDF]
Proceedings of the National Academy of Sciences, 1972 The effect of histones on accessibility of DNA to DNase in chromatin of thymus nuclei has been studied by selective extraction of either lysine-rich or arginine-rich histones. It was found that all histones block accessibility but that, weight for weight, lysine-rich histones block much more effectively than do arginine-rich histones.
A E, Mirsky, B, Silverman
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Chromatin accessibility profiling by ATAC-seq
Nature Protocols, 2022 The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a simple and scalable way to detect the unique chromatin landscape associated with a cell type and how it may be altered by perturbation or disease. ATAC-seq requires a relatively small number of input cells and does not require a priori knowledge of the epigenetic ...
Grandi, Fiorella +3 more
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HiCoP, a simple and robust method for detecting interactions of regulatory regions
Epigenetics & Chromatin, 2020 Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang +8 more
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Regulation of the Boundaries of Accessible Chromatin
PLoS Genetics, 2013 Regulatory regions maintain nucleosome-depleted, open chromatin status but simultaneously require the presence of nucleosomes for specific histone modifications. It remains unclear how these can be achieved for proper regulatory function. Here we demonstrate that nucleosomes positioned within accessible chromatin regions near the boundaries provide ...
Xiaoran Chai +4 more
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