Results 11 to 20 of about 74,613 (199)
Computational modeling of chromatin accessibility identified important epigenomic regulators
BMC Genomics, 2022 Chromatin accessibility is essential for transcriptional activation of genomic regions. It is well established that transcription factors (TFs) and histone modifications (HMs) play critical roles in chromatin accessibility regulation. However, there is a
Yanding Zhao +5 more
doaj +1 more source
Butterfly eyespots exhibit unique patterns of open chromatin [version 1; peer review: 2 approved]
F1000Research, 2023 Background: How the precise spatial regulation of genes is correlated with spatial variation in chromatin accessibilities is not yet clear. Previous studies that analysed chromatin from homogenates of whole-body parts of insects found little variation in
Suriya Narayanan Murugesan +1 more
doaj +1 more source
eLife, 2022 Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin.
Xinrui L Zhang +4 more
doaj +1 more source
HiCoP, a simple and robust method for detecting interactions of regulatory regions
Epigenetics & Chromatin, 2020 Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang +8 more
doaj +1 more source
A chromatin accessibility landscape during early adipogenesis of human adipose-derived stem cells
Adipocyte, 2022 Obesity has become a serious global public health problem; a deeper understanding of systemic change of chromatin accessibility during human adipogenesis contributes to conquering obesity and its related diseases.
Sen Li +4 more
doaj +1 more source
DNase I Chromatin Accessibility Analysis
Bio-Protocol, 2019 Chromatin consists of compacted DNA in complex with proteins and contributes to the organization of DNA and its stability. Furthermore, chromatin plays key roles in regulating cellular processes such as DNA replication, transcription, DNA repair, and ...
Brook Nepon-Sixt, Mark Alexandrow
doaj +1 more source
Journal of Integrative Agriculture, 2023 Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly ...
Si-di XIE +8 more
doaj +1 more source
Epigenetics & Chromatin, 2020 Background Chromatin dysregulation is associated with developmental disorders and cancer. Numerous methods for measuring genome-wide chromatin accessibility have been developed in the genomic era to interrogate the function of chromatin regulators.
Jake J. Reske +2 more
doaj +1 more source
Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer
Cell Reports, 2016 Chromatin regulation is critical for differentiation and disease. However, features linking the chromatin environment of stem cells with disease remain largely unknown.
Nicholas C. Gomez +5 more
doaj +1 more source
Mass Spectrometry to Study Chromatin Compaction
Biology, 2020 Chromatin accessibility is a major regulator of gene expression. Histone writers/erasers have a critical role in chromatin compaction, as they “flag” chromatin regions by catalyzing/removing covalent post-translational modifications on histone proteins ...
Stephanie Stransky +5 more
doaj +1 more source