Results 11 to 20 of about 68,994 (256)
Heparanase Modulates Chromatin Accessibility
Cells, 2023 Heparanase is the sole endoglucuronidase that degrades heparan sulfate in the cell surface and extracellular matrix (ECM). Several studies have reported the localization of heparanase in the cell nucleus, but the functional role of the nuclear enzyme is ...
Honglian Li +7 more
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Chromatin accessibility landscapes define stromal cell identities across tissues [PDF]
Communications BiologyChromatin accessibility is crucial in regulating gene expression and maintaining cellular identity. While single-cell RNA sequencing has revolutionized transcriptomic profiling, the understanding of chromatin dynamics across diverse tissues remains ...
Amin Nooranikhojasteh +6 more
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Spatially mapped single-cell chromatin accessibility [PDF]
Nature Communications, 2021 Spatial orientation of cells in an interconnected network is lost in high-throughput single-cell epigenomic assays. Here the authors present sciMAP-ATAC to produce spatially resolved single-cell ATAC-seq data.
Casey A. Thornton +12 more
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DNase I Chromatin Accessibility Analysis [PDF]
Bio-Protocol, 2019 Chromatin consists of compacted DNA in complex with proteins and contributes to the organization of DNA and its stability. Furthermore, chromatin plays key roles in regulating cellular processes such as DNA replication, transcription, DNA repair, and ...
Brook Nepon-Sixt, Mark Alexandrow
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Genome-Wide Association between Transcription Factor Expression and Chromatin Accessibility Reveals Regulators of Chromatin Accessibility. [PDF]
PLoS Computational Biology, 2017 To better understand genome regulation, it is important to uncover the role of transcription factors in the process of chromatin structure establishment and maintenance.
David Lamparter +4 more
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Profiling Chromatin Accessibility at Single-cell Resolution
Genomics, Proteomics & Bioinformatics, 2021 How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity, and enable complex fate decisions are important open questions.
Sarthak Sinha +8 more
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Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions [PDF]
MedCommCancer remains a major therapeutic challenge owing to its complex pathogenesis and the limitations of current treatments, such as poor specificity, toxicity, and multidrug resistance.
Wentao Xia +4 more
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Chromatin accessibility regulates axon regeneration
Neural Regeneration ResearchIsa Samad, Brett J. Hilton
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The Chromatin Accessibility Landscape of Adult Rat [PDF]
Frontiers in Genetics, 2021 Yue Yuan +34 more
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Regulation of chromatin accessibility by hypoxia and HIF [PDF]
Biochemical Journal, 2022 Reduced oxygen availability (hypoxia) can act as a signalling cue in physiological processes such as development, but also in pathological conditions such as cancer or ischaemic disease. As such, understanding how cells and organisms respond to hypoxia is of great importance.
Michael Batie +3 more
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