Results 21 to 30 of about 68,994 (256)
Chromatin accessibility: a window into the genome [PDF]
Epigenetics & Chromatin, 2014 Transcriptional activation throughout the eukaryotic lineage has been tightly linked with disruption of nucleosome organization at promoters, enhancers, silencers, insulators and locus control regions due to transcription factor binding. Regulatory DNA thus coincides with open or accessible genomic sites of remodeled chromatin.
Tsompana, Maria, Buck, Michael J
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Computational modeling of chromatin accessibility identified important epigenomic regulators
BMC Genomics, 2022 Chromatin accessibility is essential for transcriptional activation of genomic regions. It is well established that transcription factors (TFs) and histone modifications (HMs) play critical roles in chromatin accessibility regulation. However, there is a
Yanding Zhao +5 more
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eLife, 2022 Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin.
Xinrui L Zhang +4 more
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Evolution and genetic architecture of chromatin accessibility and function in yeast. [PDF]
PLoS Genetics, 2014 Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed ...
Caitlin F Connelly +2 more
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Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation
Frontiers in Cell and Developmental Biology, 2021 Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang +11 more
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Transcription factor access to chromatin [PDF]
Nucleic Acids Research, 1997 The question of how sequence-specific transcription factors access their cognate sites in nucleosomally organized DNA is discussed on the basis of genomic footprinting data and chromatin reconstitution experiments. A classification of factors into two categories is proposed: (i) initiator factors which are able to bind their target sequences within ...
M, Beato, K, Eisfeld
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SeATAC: a tool for exploring the chromatin landscape and the role of pioneer factors
Genome Biology, 2023 Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) reveals chromatin accessibility across the genome. Currently, no method specifically detects differential chromatin accessibility.
Wuming Gong +2 more
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A chromatin accessibility landscape during early adipogenesis of human adipose-derived stem cells
Adipocyte, 2022 Obesity has become a serious global public health problem; a deeper understanding of systemic change of chromatin accessibility during human adipogenesis contributes to conquering obesity and its related diseases.
Sen Li +4 more
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Profiling single-cell chromatin accessibility in plants
STAR Protocols, 2021 Summary: Coupling assay for transposase-accessible chromatin sequencing (ATAC-seq) with microfluidic separation and cellular barcoding has emerged as a powerful approach to investigate chromatin accessibility of individual cells.
Alexandre P. Marand +4 more
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Cations and the accessibility of chromatin to nucleases [PDF]
Nucleic Acids Research, 1979 When rat liver nuclei prepared with polyamines as stabilising cations are digested with DNAase II, release of both inactive chromatin and Mg-soluble, active chromatin is greatly reduced, in comparison to digestion of liver nuclei prepared with Mg2+ as stabilising cation.
M A, Billett, T J, Hall
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