Results 81 to 90 of about 2,931,165 (316)

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

open access: yesCardiovascular Diabetology, 2018
Background Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation and the risk for cardiovascular disease (CVD) could be increased in PCOS.
Dorte Glintborg   +4 more
doaj   +1 more source

Open Data Exposed

open access: yes, 2018
This book is about open data, i.e. data that does not have any barriers in the (re)use. Open data aims to optimize access, sharing and using data from a technical, legal, financial, and intellectual perspective. Data increasingly determines the way people live their lives today.
Joep Crompvoets   +4 more
openaire   +6 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Old wine, new bottle? Principi e metodi per una reale innovazione nelle prospettive LIS. Il parere di Marshall Breeding, Mauro Guerrini, David Weinberger, Paul Gabriele Weston, Maja Žumer

open access: yesAIB Studi, 2015
Il saggio è costituito da interviste a Marshall Breeding, Mauro Guerrini, David Weinberger, Paul Gabriele Weston e Maja Žumer, realizzate ponendo tre domande a queste figure riconosciute a livello internazionale. Tramite questo saggio il Gruppo di studio
Gruppo di studio AIB CILW
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

L’universo delle risorse culturali: lampi di genio e azioni concrete. Lightning talks presentati al Convegno AIB CILW 2016

open access: yesAIB Studi, 2017
Sono raccolti sei dei sette lightning talks presentati al Convegno AIB CILW 2016, nell’ambito della sessione aperta al contributo di qualunque studioso delle tematiche proposte nell’incontro.
Gruppo di studio AIB CILW
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

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