Results 41 to 50 of about 2,040,526 (286)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Open Educational Resources and Informational Ecosystems: «Edutags» as a connector for open learning
MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung, 2014 Teaching and learning in school essentially relies on analogous and digital media, artefacts and tools of all kinds. They are supported and provided by various players.
Michael Kerres, Richard Heinen
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Journal of Open, Flexible and Distance Learning, 2011 This article explores the relationship between academic disciplines’ representation in the United Kingdom Open University’s (OU) OpenLearn open educational resources (OER) repository and in the OU’s fee-paying curriculum.
Tony Coughlan, Leigh-Anne Perryman
doaj +2 more sources
Sharing Resources in Open Educational Communities
Qualitative Research in Education, 2014 The spread of Internet and the latest Web developments have promoted the relationships between teachers, learners and institutions, as well as the creation and sharing of new Open Educational Resources (OERs).
Paolo Tosato +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Open Educational Resources in virtual teaching communities
Apertura, 2021 Formative models related to the theory of connectivism are increasingly flexible, open and participatory. Under this trend, ideas such as virtual teaching communities (VCT) or Open Educational Resources (OER) have been widespread, which lead us to talk ...
Joaquín Recio Mayorga +2 more
doaj +1 more source
The University of New Hampshire Open Educational Resources Survey [PDF]
, 2017 The University of New Hampshire Survey Center conducted a survey of UNH faculty members about their usage, understanding, and needs from the University\u27s Open Educational Resources (OER) program. An email invitation to complete the internet survey was
Keirns, Tracy, McKinley, Sean P.
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source