Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Effects of Visual Communication Design Accessibility (VCDA) Guidelines for Low Vision on Public and Open Government Health Data. [PDF]
Healthcare (Basel), 2023 Lim J, Kim W, Kim I, Lee E.
europepmc +1 more source
Tariff and Equilibrium Indeterminacy--(II) [PDF]
We establish conditions under which indeterminacy can occur in a small open economy oil-in the production RBC model with lump sum tariff revenue transfers. The indeterminacy would require that the steady state tariff rates be in an open interval.
Zhang, Yan
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Transparency in government institutions: a literature review
Brazilian Journal of Operations & Production Management, 2014 This paper presents a literature review on the issue of transparency in government institutions. The review is carried out through a bibliometric survey of the Scopus database, brazilian government websites, and brazilian legislation. The review explores
Carlos Soares Dos Santos +4 more
doaj
Factors influencing open government data post-adoption in the public sector: The perspective of data providers. [PDF]
PLoS One, 2022 Mustapa MN, Hamid S, Md Nasaruddin FH.
europepmc +1 more source
Balanced Budget Government Spending in a Small Open Regional Economy [PDF]
This paper investigates the impact of a balanced budget fiscal policy expansion in a regional context within a numerical dynamic general equilibrium model.
Kim Swales +2 more
core
Artigas workers: An open letter to Artigas, brand companies, the local government, and society [PDF]
, 2015 This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
China Labor Watch
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Gobierno abierto y modernización de la gestión Pública. Tendencias actuales y el (inevitable) camino que viene. Reflexiones seminales [PDF]
Revista Enfoques, 2011 The concept of Open Government is not a new one. It was used for the first time in British politics in the late 1970’s and at its inception it was related with a number of issues about government secrecy and efforts to “open windows” for the public ...
Álvaro V. Ramírez-Alujas
doaj