Results 141 to 150 of about 3,992,544 (296)

Using mixed methods to track the growth of the Web: tracing open government data initiatives

open access: yes, 2012
In recent years, there have been a rising number of Open Government Data (OGD) initiatives; a political, social and technical movement armed with a common goal of publishing government data in open, re-usable formats in order to improve citizen-to ...
Carr, Leslie   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Open Access, Law, Knowledge, Copyrights, Dominance and Subordination [PDF]

open access: yes, 2006
The concept of open access to legal knowledge is at the surface a very appealing one. A citizenry that is well informed about the law may be more likely to comply with legal dictates and proscriptions, or at a minimum, will be aware of the consequences ...
Bartow, Ann
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

U.S. SDG Data Revolution Roadmap [PDF]

open access: yes, 2017
One year after adopting the SDGs, in an addendum to its Open Government National Action Plan, the U.S. Government committed to develop an SDG Data Revolution Roadmap that "charts the future course of efforts to fill data gaps and build capacity to use ...
Aditya Agrawal   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Habit Formation and Fiscal Transmission in Open Economies [PDF]

open access: yes
In this paper we analyze the ability of an open economy version of the neoclassical model to account for the time-series evidence on fiscal policy transmission. In a first step, we identify government spending shocks within a vector autoregression model.
Gernot J. Muller, Olivier Cardi
core  

Chatbots as a novel access method for government open data [PDF]

open access: yes, 2017
IIn this discussion paper, we propose to employ chatbots as a user-friendly interface for open data published by organizations, specifically focusing on public administrations.
Catarci, Tiziana   +3 more
core  

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