Results 71 to 80 of about 2,886,776 (296)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

AI-Driven Smart Agriculture: An Integrated Approach for Soil Analysis, Irrigation, and Crop-Fertilizer Recommendations

open access: yesIEEE Access
Modern agriculture faces critical challenges, including climate change induced water shortage, inefficient resource utilization, and reducing soil health which reduce sustainability and reduce crop yields. Traditional farming methods, dependent on manual
Ayesha Khaliq   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Building an Open Social Learning Community Around a DSpace Repository on Statistics [PDF]

open access: yes, 2009
4th International Conference on Open RepositoriesThis presentation was part of the session : Conference PostersIn this paper we describe a project which aims to build an open social learning community around a learning object repository (LOR) based on ...
Córcoles, Cesar P.   +2 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Using the Eisenhower Matrix to Identify Open Government Data Parameter Towards Information Disclosure in Indonesia

open access: yesBuletin Pos dan Telekomunikasi: Media Komunikasi Ilmiah
The openness of government data is considered essential and is an influential innovation in society to prevent corruption by increasing the transparency of information and data.
Herma Adis, Catur Apriono
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Open data appetite: How nations' hunger for open government data varies with their economic complexity [PDF]

open access: yes, 2015
There are significant cross-national differences in government data openness.The research takes an economic complexity perspective to help explain this phenomenon.It theoretically explores the notion that data openness is more valuable to complex ...
Savenkov, Anthony
core  

Emerging Roles for Optimising Re-Use of Open Government Data [PDF]

open access: yes, 2018
This paper describes a small-scale study to investigate the missions, services and operational tasks provided by four open government data centers: NYC OpenData (New York Open Data Center), DataSF (open data portal of San Francisco), WPRDC (Western ...
Gradeck, Robert M.   +3 more
core   +2 more sources

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