Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Relationship network, knowledge transfer and open innovation behavior of SMEs from China. [PDF]
PLoS OneNi M, Wang M.
europepmc +1 more source
Responsiveness of open innovation to COVID-19 pandemic: The case of data for good. [PDF]
PLoS One, 2022 Scotti F +3 more
europepmc +1 more source
Openness and innovation performance: are small firms different? [PDF]
Traditionally, literature on open innovation has concentrated on analysis of larger firms. We explore whether and how the benefits of openness in innovation are different for small firms (less than 50 employees) compared to medium and large ones.
James Love, Priit Vahter, Stephen Roper
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The impact of digital transformation on open innovation performance: The intermediary role of digital innovation dynamic capability. [PDF]
PLoS OneQiu P, Chang B.
europepmc +1 more source
The Construction of Ecosystem and Collaboration Platform for Enterprise Open Innovation.
Front Psychol, 2022 Wang M +4 more
europepmc +1 more source
Open, distributed and user-centered: Towards a paradigm shift in innovation policy [PDF]
Today's innovation policies ignore that innovation is increasingly open, distributed and user-centered. In this paper we introduce the user-centered model as an alternative paradigm of how innovation 'works'.
Eric von Hippel, Jeroen de Jong
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source