Results 51 to 60 of about 2,286,604 (339)
CORPORATE CHALLENGE CANVAS: FERRAMENTA VISUAL PARA SISTEMATIZAR DESAFIOS DE OPEN INNOVATION / CORPORATE CHALLENGE CANVAS: VISUAL TOOL TO SYSTEMATIZE OPEN INNOVATION CHALLENGES [PDF]
, 2022 THAIS DE CARVALHO LARCHER PINTO +1 more
openalex +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Open Innovation and Coopetition
Abstract While the open innovation literature has acknowledged competitors as a source of innovative knowledge, competitors have been relatively neglected relative to other sources such as universities, suppliers, customers, and employees.
Bez, Sea Matilda, Le Roy, Frédéric
openaire +3 more sources
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
, 2018 Since the publication of Open Innovation: The new imperative for creating and profiting from technology from Henry Chesbrough, the interest for Open Innovation grew dramatically in the last 15 years. According to the author, Open Innovation can be defined as “the purposive inflows and outflows of knowledge to accelerate internal innovation, and expand ...
+7 more sources
Living labs for in-situ open innovation: from idea to product validation and beyond [PDF]
, 2014 In this paper we present the Living Lab methodology as an overall framework for in-situ open innovation involving the end-user as equal participant in the innovation process.
Baccarne, Bastiaan +6 more
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Open Source System as Innovation in Organizations: a Managerial Perspective on Its Adoption [PDF]
, 2014 This study identifies the factors that have a direct effect on a manager's decision towards Open Source System (OSS) enterprise system adoption in Malaysia.
Jaafar, N. I. (Noor) +1 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Scientific Reports, 2023 To achieve a sustainable human presence on the Moon, it is critical to develop technologies utilising the local resources (a.k.a. in-situ resource utilisation or ISRU) for construction and resource extraction.
Sungwoo Lim +4 more
doaj +1 more source