Results 71 to 80 of about 788,297 (312)

Multi-sided platforms as catalysts for responsible innovation in healthcare: Patient Innovation as a case-study

Journal of Responsible Innovation
Healthcare systems face increasing pressure from aging populations, chronic diseases, and the demand for accessible, high-quality care. Yet many innovations fail to address the needs of vulnerable groups.
Gemma Tria, Maria João Jacinto, Margarida Oliveira, Helena Canhão, Pedro Oliveira   +4 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Developing a framework for measuring open innovation in defense industry [PDF]

بهبود مدیریت, 2019
Evidence in defense industry including knowledge dispersion and budget cuts demonstrate increasingly necessity of moving toward open innovation as defense industry in united states of America, England, and many other countries are opening their ...
Ebrahim Sozanchi Kashani, Hossein Arjini, Mehdi Moghayadnia   +2 more
doaj  

Do we teach what we research? unfolding absorptive capacity,open innovation, management innovation and clusters

, 2012
El presente Taller de Estrategia Empresarial, es un workshop internacional organizado por la Sección de Estrategia Empresarial de la asociación ACEDE, que se celebrará en Valencia en enero de 2012.
Hervás Oliver, Jose Luis
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Connected innovation: an international comparative study that identifies mixed modes of innovation

, 2011
This paper offers a new angle on innovation modalities by adopting a recently emerging approach towards identifying innovation typologies via exploratory data analysis techniques with the aim to tease out some underlying latent variables that represent ...
Frenz, Marion, Lambert, R.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Intellectual Structure of the Open Innovation Field: State of the Art and a Critical Literature Review

Economic and Business Review, 2018
This paper presents an overview of open innovation. It positions the concept into a wider framework of scholarly research of innovation, discusses its historical development and its positioning within the wider area of innovation research.
Aleš Pustovrh, Marko Jaklič
doaj   +1 more source

The role of open innovation in biomarker discovery

, 2016
Precision medicine aims to treat diseases with special consideration for the individual biological variability. Novel biomarkers (BM) are needed to predict therapeutic responses and to allow for the selection of suitable patients for treatment with ...
Gottwald, Matthias, Matthias Gottwald, Khusru Asadullah, Andreas Busch, Landeck, Lilla, Monika Lessl, Asadullah, Khusru, Lilla Landeck, Busch, Andreas, Lessl, Monika   +9 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source