Results 91 to 100 of about 19,215,092 (251)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Open innovation in SMEs: Trends, motives and management challenges [PDF]

Although evidence for open innovation practices has been provided for large MNEs, they have not yet been analyzed systematically for SMEs. This paper presents the results of a survey among 605 Dutch innovating SMEs.
Jeroen de Jong, Wim Vanhaverbeke, Maurice de Rochemont, Vareska van de Vrande   +3 more
core  

Evolutionary game study of crowdsourcing open innovation synergy mechanism. [PDF]

Heliyon, 2023
Jiang Y, Zhang L, Wu J.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

OPEN ECO-INNOVATION DIGITAL PLATFORM MODELLING FOR TEXTILE

reservedTextile is one of the important industries that have a negative impact on humans and the environment. As a result of that sustainable innovations and strategies have gained more importance in the last years in the industry.
KOSE, NERMIN
core  

Examination of the impact of curiosity and fatigue on brain condition

Scientific Reports
With a growing emphasis on cognitive well-being, this study investigates factors influencing brain health, measured by Fractional Anisotropy Brain Healthcare Quotient (FA-BHQ).
Yan Ni, Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Teacher practices regarding teaching presence in Vietnamese tertiary online distance education programmes

Humanities & Social Sciences Communications
This study explored how teachers adapt their agentic teaching practices in the context of online distance education programmes in Vietnam. A single-institution case study design was used to collect data through online individual semistructured interviews
Phong Thanh Nguyen, Luan Thanh Nguyen, Vu Mau Nguyen   +2 more
doaj   +1 more source

Green innovation behaviour: Impact of industry 4.0 and open innovation. [PDF]

Heliyon, 2023
Ogiemwonyi O, Alam MN, Hago IE, Azizan NA, Hashim F, Hossain MS.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source