Results 101 to 110 of about 788,297 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Exploration-exploitation transitions in open innovation : from preaching to practice

, 2008
This conceptual paper considers the potential for process innovation tools, such as stage-gate techniques, to ease transitions from exploration to exploitation activities in the context of Open Innovation.
Fitzgerald, Anneke (R10311), Smulders, Frido J., Hayes, Kathryn J. (R12313)   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Open innovation in science

Openness and collaboration can foster breakthroughs in science and science-based innovation. As such, they can help address declining scientific productivity and tackle grand challenges of the present day.
Beck, S., Sauermann, H., Poetz, M., Grimpe, C.   +3 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Examination of the impact of curiosity and fatigue on brain condition

Scientific Reports
With a growing emphasis on cognitive well-being, this study investigates factors influencing brain health, measured by Fractional Anisotropy Brain Healthcare Quotient (FA-BHQ).
Yan Ni, Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa   +3 more
doaj   +1 more source

Evolutionary game study of crowdsourcing open innovation synergy mechanism. [PDF]

Heliyon, 2023
Jiang Y, Zhang L, Wu J.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Teacher practices regarding teaching presence in Vietnamese tertiary online distance education programmes

Humanities & Social Sciences Communications
This study explored how teachers adapt their agentic teaching practices in the context of online distance education programmes in Vietnam. A single-institution case study design was used to collect data through online individual semistructured interviews
Phong Thanh Nguyen, Luan Thanh Nguyen, Vu Mau Nguyen   +2 more
doaj   +1 more source

Evaluation of the Quality Protein and the Effect on Muscle Health of a New Ingredient Based on Hydrolyzed Egg White

Proceedings
Concerns about the growing human population and how to supply future nutritional needs have translated to a growing interest in searching for alternative proteins.
Lidia Tomás-Cobos, Elisa Gallego, Elena Diez-Sánchez, Laura Soriano-Romaní, María Eugenia Juncal-Fernández, Raul da Pereira-Rouco, María Pereda-Legaspi   +6 more
doaj   +1 more source