Results 121 to 130 of about 2,501,794 (292)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Rethinking Open Innovation Beyond the Innovation Funnel [PDF]

Technology Innovation Management Review, 2013
In his article, I first argue that open innovation can be applied in situations where companies do not themselves develop new products or services.
Wim Vanhaverbeke
doaj  

Open innovation: the key to advancing brain health. [PDF]

CNS Spectr, 2023
Eyre HA, Searfoss J, Hopwood M, Berk M, Chen S, Cummings J, Veron F, Zikopoulou V, Ibanez A, Kelly K, Soares JC, Smith E, Gilbert BJ.   +12 more
europepmc   +1 more source

Open Innovation in a Dynamic Cournot Duopoly [PDF]

We analyze an Open Innovation process in a Cournot duopoly using a differential game approach where knowledge spillovers are endogenously determined via the R&D process.
A. Palestini, I. Hasnas, L. Lambertini
core  

Open Access Pump-Priming Expenditure Report University of Glasgow [PDF]

, 2013
Report on activity undertaken with a grant of £360k from the Department for Business, Innovation and Skills in support of Open Access to research ...
McCutcheon, V.
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Multi-disciplinary Perspectives on Citizen Science—Synthesizing Five Paradigms of Citizen Involvement

Citizen Science: Theory and Practice
Research on Open Innovation in Science (OIS) investigates how open and collaborative practices influence the scientific and societal impact of research. Since 2019, the OIS Research Conference has brought together scholars and practitioners from diverse ...
Susanne Beck, Dilek Fraisl, Marion Poetz, Henry Sauermann   +3 more
doaj   +1 more source

Is 'Open Innovation' Re-Inventing Innovation Policy for Catching-up Economies? [PDF]

This paper discusses the current state of the .open innovationÿ thinking in the context of core economic challenges faced by catching-up and developing countries. The main argument of the paper is that due to the paradoxes and contradictions between the .
Erkki Karo, Rainer Kattel
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Detection of Glutamate Encapsulated in Liposomes by Optical Trapping Raman Spectroscopy

ACS Omega, 2022
Kyoko Masui, Yasunori Nawa, Shunsuke Tokumitsu, Takahiro Nagano, Makoto Kawarai, Hirokazu Tanaka, Tatsuki Hamamoto, Wataru Minoshima, Tomomi Tani, Satoshi Fujita, Hidekazu Ishitobi, Chie Hosokawa, Yasushi Inouye   +12 more
doaj   +1 more source