Open collective innovation [PDF]
, 2014 Report published by Advanced Institute of Management ResearchThe innovation context is changing. The production of knowledge is accelerating. Knowledge creation is now a globally distributed activity.
Bessant, John, Möslein, Kathrin
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Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Open Innovation as the Catalyst in the Personalized Medicine to Personalized Digital Medicine Transition. [PDF]
J Pers Med, 2022 Cesario A +5 more
europepmc +1 more source
Open source innovation: Characteristics and applicability outside the software industry [PDF]
Motivation of this paper is to discuss that the open source model of innovation does not only seem practical in the software industry, but also in various other industrial contexts.
Abdelkafi, Nizar +2 more
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Widening the Pool: Open and Inclusive Grant Competitions: Lessons Learned From the Social Innovation Fund [PDF]
, 2012 Offers guidance on implementing transparent and competitive grantmaking processes as required by the Social Innovation Fund, including the benefits of transparency, key design considerations such as clear criteria, and examples of open ...
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Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Linking solver characteristics, solving processes and solution attributes: A data explainer for an open innovation generated robotic design dataset. [PDF]
Data Brief, 2023 Szajnfarber Z +4 more
europepmc +1 more source
Methodological Guide to Co-design Climate-smart Options with Family Farmers [PDF]
, 2018 Climate-smart agriculture (CSA) seeks to improve productivity for the achievement of food security (pillar 1: Productivity), to develop a better ability to adapt (pillar 2: Adaptation), and to limit greenhouse gas emissions (pillar 3: Mitigation ...
Acosta-Alba, Ivonne +5 more
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source