Results 131 to 140 of about 19,215,092 (251)

Measuring Open Innovation in the Bio-Pharmaceutical Industry

, 2015
The paper suggests a model for measuring the degree of openness of innovation in firms through the analysis of their annual reports. Two indicators are defined: open innovation generated value, which measures the intensity of outbound processes, and open
CAPUTO, Mauro, LAMBERTI, EMILIA, MICHELINO, FRANCESCA, CAMMARANO, ANTONELLO   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Open Innovation as the Catalyst in the Personalized Medicine to Personalized Digital Medicine Transition. [PDF]

J Pers Med, 2022
Cesario A, D'Oria M, Simone I, Patarnello S, Valentini V, Scambia G.   +5 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Open innovation during the COVID-19 pandemic policy responses in South Africa and Kenya. [PDF]

Polit Policy, 2022
Onyango G, Ondiek JO.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Linking solver characteristics, solving processes and solution attributes: A data explainer for an open innovation generated robotic design dataset. [PDF]

Data Brief, 2023
Szajnfarber Z, Hennig A, Mukherjee S, Rader S, Crusan J.   +4 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A Systemic Approach for Designing Open Innovation Value Networks [PDF]

The past two decades have seen a number of changes to the business and technological environment that have favored the rise of “open” collaborative innovation as alternative to the more traditional ”closed” models. The traditional view of innovation as a
Wegmann, Alain, Golnam, Arash, Regev, Gil, Hegarty, Aoife   +3 more
core   +1 more source

Designing of an open innovation model in science and technology parks. [PDF]

J Innov Entrep, 2022
Bayat P, Daraei M, Rahimikia A.
europepmc   +1 more source