Results 111 to 120 of about 19,215,092 (251)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Stakeholder network for developing open innovation practice of China's manufacturing enterprises. [PDF]

Heliyon, 2023
Lyu B, Yi R, Fan G, Zhang Y.
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Detection of Glutamate Encapsulated in Liposomes by Optical Trapping Raman Spectroscopy

ACS Omega, 2022
Kyoko Masui, Yasunori Nawa, Shunsuke Tokumitsu, Takahiro Nagano, Makoto Kawarai, Hirokazu Tanaka, Tatsuki Hamamoto, Wataru Minoshima, Tomomi Tani, Satoshi Fujita, Hidekazu Ishitobi, Chie Hosokawa, Yasushi Inouye   +12 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Enabling and Sustaining Collaborative Innovation [PDF]

This paper extends the principles of open source software development to a non-industry-specific level by introducing the Open Source Innovation (OSI) model.
Raasch, Christina, Abdelkafi, Nizar, Blecker, Thorsten   +2 more
core  

Broker roles in open innovation

Knowledge brokers play a crucial role in open innovation. We use exponential random graph models and qualitative analysis of semi-structured interview data to contrast knowledge brokerage in three open innovation partnerships. Our analysis considers both
Wang, P., Elsum, I., Bolton, Dianne (R21308), Lusher, D., Terhorst, A.   +4 more
core   +1 more source

Open Innovation and Knowledge Management in SMEs: What Comes Next?

, 2018
The aim behind this final chapter is to propose and discuss a number of topics that could build the basis for future research regarding the interplay between knowledge management (KM) and open innovation (OI) in SMEs.
Durst, Susanne,, Serdal Temel, Temel, Serdal,, Susanne Durst   +3 more
core   +1 more source

Evaluation of the Quality Protein and the Effect on Muscle Health of a New Ingredient Based on Hydrolyzed Egg White

Proceedings
Concerns about the growing human population and how to supply future nutritional needs have translated to a growing interest in searching for alternative proteins.
Lidia Tomás-Cobos, Elisa Gallego, Elena Diez-Sánchez, Laura Soriano-Romaní, María Eugenia Juncal-Fernández, Raul da Pereira-Rouco, María Pereda-Legaspi   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source