Results 81 to 90 of about 788,297 (312)

Open Innovation Technologies and Exploitative and Explorative Learning

, 2012
Many organisations are embracing the open innovation approach. However, becoming open to ideas coming from outside requires a revision of their innovation processes in order to integrate external and internal ideas effectively. The aim of this chapter is
Mats Edenius, Edenius, Mats, Yakhlef, Ali,, Ali Yakhlef   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Cross-pollination Approach: Conditions for Incubating and Cascading Collaborative Civic Design Initiatives

She Ji: The Journal of Design, Economics and Innovation
Integrative civic leadership, which builds on the capabilities of individuals and organizations across sectors and communities, is essential to sustainable and inclusive placemaking.
Katerina Alexiou, Vera Hale, Sophia de Sousa, Theodore Zamenopoulos   +3 more
doaj   +1 more source

An experiment in online AT open innovation

, 2011
Objective. To initiate an experiment to see if an online tool can facilitate creation of new Assistive Technology (AT) through open innovation that engages the public (primarily end users and carers), prescribers, innovators and manufacturers.
Wald, Mike, Cudd, Peter, Skuse, Sebastian, Draffan, E.A., Lee, Steve   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Outlier Detection for Minor Compositional Variations in Taxonomic Abundance Data

Applied Sciences, 2019
To understand the activities of complex microbial communities in various natural environments and living organisms, we need to capture the compositional changes in their taxonomic abundance.
Koji Ishiya, Sachiyo Aburatani
doaj   +1 more source

Open innovation in SMEs: Trends, motives and management challenges [PDF]

Although evidence for open innovation practices has been provided for large MNEs, they have not yet been analyzed systematically for SMEs. This paper presents the results of a survey among 605 Dutch innovating SMEs.
Jeroen de Jong, Wim Vanhaverbeke, Maurice de Rochemont, Vareska van de Vrande   +3 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Investigating the thermal and localised stress induced effects on discontinuous dynamic recrystallisation behaviour of CuCrZr alloy for fusion devices

Materials & Design
Copper-Chromium-Zirconium alloys are candidate heat sink materials for divertors in fusion devices. The heat sinks are used to keep divertor temperatures under control, and will be subjected to high thermal loads, neutron irradiation and high stress ...
Parth Kulkarni, Muhammad Zeeshan Mughal, Ellies Muyupa, Ashutosh Bhagurkar, Benjamin Poole, Allan Harte, Rory Spencer, Salih Gungor, Richard Moat, Alexander Forsey   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source