Results 51 to 60 of about 788,297 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Physiological Sciences, 2023 We evaluated the reliability of a newly developed wearable ear canal thermometer based on three different experiments, in which ear canal and rectal temperature (Tear and Trec, respectively) were simultaneously monitored.
Issei Kato +2 more
doaj +1 more source
This book comprehensively discusses the cooperation of corporations with startups in the context of accelerator programs. It focuses on recognizing how open innovation can catalyze startups’ development and success, and benefit corporations through ...
Bańka, Michał
core +1 more source
Open Innovation in Brazil: Exploring Opportunities and Challenges [PDF]
, 2019 While open innovation has been increasingly adopted in developed countries, firms from emerging markets such as Brazil markedly fall behind this trend.
Chesbrough, Henry +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Voluntary Contributors in Open Innovation Processes
, 2012 There is a trend among many organisations to open up their innovation processes and invite more stakeholders to contribute to it. One of these stakeholders is the voluntary contributor.
Birgitta Bergvall-Kåreborn +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Open Innovation and Coopetition
Abstract While the open innovation literature has acknowledged competitors as a source of innovative knowledge, competitors have been relatively neglected relative to other sources such as universities, suppliers, customers, and employees.
Bez, Sea Matilda, Le Roy, Frédéric
openaire +3 more sources
Open innovation ecosystems [PDF]
, 2023 Defined as a community of hierarchically independent, yet interdependent heterogeneous actors around a focal firm who facilitate innovation through cross-boundary knowledge flows, the open innovation ecosystem extends scholarly understanding of open ...
Ritala, Paavo, Thomas, Llewellyn D. W.
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source