Results 41 to 50 of about 295,237 (301)

Open Innovation Research, Management and Practice [PDF]

, 2013
The concept of open innovation has become increasingly popular in the management and policy literature on technology and innovation. However, despite the large volume of empirical work, many of the prescriptions being proposed are fairly general and not specific to particular contexts and contingencies. The proponents of open innovation are universally
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Value capture in open innovation markets: the role of patent rights for innovation appropriation [PDF]

, 2022
PurposeThe role of patents for appropriating (capturing) value from innovation investments has for decades been of major interest to both practitioners and academics in innovation management.
Holgersson, Marcus,, Granstrand, Ove, Holgersson, Marcus, Granstrand, Ove,   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Broadening the scope of open innovation: past research, current state and future directions

, 2010
In this first paper of the special issue, we identify some trends in open innovation research by analysing how the literature on this topics has evolved since the introduction of the concept in 2003.
Vanhaverbeke, W, Vanhaverbeke, Wim, van de Vrande, Vareska, Wim Vanhaverbeke, Gassmann, O, Vrande, Vareska Van de, Gassmann, Oliver, Vareska Van de Vrande, van de Vrande, Vareska; id_orcid, Oliver Gassmann   +9 more
core   +1 more source

R&D Management Practices and Innovation: Evidence from a Firm Survey [PDF]

, 2022
This Open Access book provides a detailed account of firms’ research and development (R&D) management practices, and whether and how R&D management practices are associated with the success and the nature (explorative or exploitive) of innovation, using ...
Ono, Arito, Haneda, Shoko
core   +1 more source

Critical Aspects of the Innovation Management: the cases Natura and Oxiteno

International Journal of Innovation, 2017
This study has as its objective to analyze the critical aspects of the innovation management in terms of structure, strategy and processes of innovation of the Natura and Oxiteno companies.
Sheila Serafim da Silva, Eduardo Pinheiro Gondim de Vasconcellos, Murilo Alvarenga Oliveira, Renata Giovinazzo Spers   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source