Results 41 to 50 of about 24,895,646 (251)

A Survey on the Relationship Between Knowledge Management with Job Performance and Open Innovation in Employees of West Regional Electric Company [PDF]

تحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2019
Purpose: The purpose of this study was to investigate the relationship between knowledge management and job performance and open innovation among West Regional Electric Company employees.Method: The research method was descriptive correlational and the ...
faramarz soheili, saleh rahimi, Fatemeh Aivatvandy pour   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Open Service Innovation in Health Care: What Can We Learn from Open Innovation Communities?

, 2012
The purpose of the chapter is to describe and discuss how principles from open innovation, which are primarily derived from commercial product development, could be applied to open service innovation in non-profit health care organisations.
Edenius, Mats,, Mats Edenius, Christina Keller, Lindblad, Staffan,, Keller, Christina,, Staffan Lindblad   +5 more
core   +1 more source

Critical Aspects of the Innovation Management: the cases Natura and Oxiteno

International Journal of Innovation, 2017
This study has as its objective to analyze the critical aspects of the innovation management in terms of structure, strategy and processes of innovation of the Natura and Oxiteno companies.
Sheila Serafim da Silva, Eduardo Pinheiro Gondim de Vasconcellos, Murilo Alvarenga Oliveira, Renata Giovinazzo Spers   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Managing Open Innovation: Exploring Challenges at the Interfaces of an Open Innovation Arena

, 2011
Collaborating with peers to gain access to knowledge is an attractive alternative for organizations keen to improve their innovativeness, and the rising popularity of open innovation has resulted in the emergence of new actors in the innovation process ...
Ollila, Susanne, Ollila, Susanne,, Elmquist, Maria, Elmquist, Maria,, Susanne Ollila, Maria Elmquist   +5 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Building an internationally oriented open regional innovation system : a paradox perspective [PDF]

, 2019
An open regional innovation system is often characterised by the firms' adoption of an open innovation strategy, which is closely linked to absorptive capacity. This study explores the effects of the firms' absorptive capacity on open regional innovation
Kuusisto, Arja, Liang, Liting S.
core