Results 41 to 50 of about 1,007,234 (319)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser +5 more
wiley +1 more source
Energy saving and energy efficiency policies in the European union
Известия высших учебных заведений: Проблемы энергетики, 2017 This article analyses energy saving and energy efficiency policies in the European Union. Directives EU in this area since 1993 are described. The basic provisions of the Directive 2012/27 on energy efficiency and Energy Efficiency Plan 2011 are analyzed.
S. T. Kasyuk
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
CSDP and the open method of coordination: Developing the EU's comprehensive approach to security [PDF]
Journal of Regional Security, 2017 How can we best describe the operation of the Common Security and Defence Policy (CSDP), and how can we improve policy-making in CSDP? The Open Method of Coordination (OMC) is predicated on the conviction that there are clear limits to the extent that ...
Sweeney Simon, Winn Neil
doaj
The Journal of Engineering, 2019 Power electronic devices such as soft open point (SOP) and voltage source converter (VSC) begin to be applied to distribution networks, which are developed into hybrid AC/DC distribution networks.
Pengwei Cong +4 more
doaj +1 more source
Research on Automatic Identification of Marked Parallel Structures in Chinese Patent [PDF]
Jisuanji gongcheng, 2018 The Coordination with Overt Conjunctions(COCs)in the Chinese patent literature are complex and widely distributed.The existing recognition technology can only use limited features to identify some simple types of parallel structures,and the recognition ...
LIU Xiaodie,ZHU Yun,JIN Yaohong
doaj +1 more source
EU and OECD benchmarking and peer review compared [PDF]
, 2009 Benchmarking and peer review are essential elements of the so-called EU open method of coordination (OMC) which has been contested in the literature for lack of effectiveness.
Groenendijk, Nico
core +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source