Results 51 to 60 of about 178,958,361 (288)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Application of evolutionary algorithms for optimal directional overcurrent relay coordination [PDF]
, 2014 Includes bibliographical references.Relay coordination is necessary to ensure that while protection relays operate as fast as possible, they are also able to isolate only the faulted parts of the system from the network, ensuring that a power system ...
Stenane, Ndabeni Moses
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Economic Policy Coordination and Policy Regimes in the European Union. EPIN Working Paper No. 2, July 2002 [PDF]
, 2002 [From the Introduction]. This paper discusses three regimes for the coordination of economic policies in the EC Treaty – "pillar one" of the European Union – namely the Single Market, macro-economic policy coordination, and the Open Coordination Method ...
Micossi, Stafano.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The open method of coordination and lifelong guidance [PDF]
, 2016 This article displays the importance of career guidance in Europe and beyond. The authors provide insight into the Open Method of Coordination (OMC), where mutual peer learning and development is of high importance. This paper highlights some of the elements of OMC in career guidance, discussing the terms “benchmarking”, “peer learning” and ...
Plant, Peter, Kjærgård, Roger
openaire +2 more sources
Research on Automatic Identification of Marked Parallel Structures in Chinese Patent [PDF]
Jisuanji gongcheng, 2018 The Coordination with Overt Conjunctions(COCs)in the Chinese patent literature are complex and widely distributed.The existing recognition technology can only use limited features to identify some simple types of parallel structures,and the recognition ...
LIU Xiaodie,ZHU Yun,JIN Yaohong
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Kinesiologia Slovenica, 2013 The aim of this paper is to propose an analytical framework for monitoring public governance in sport. In the paper’s literature review, we first discuss the key characteristics of monitoring systems and public governance approaches.
Simona Kustec Lipicer, Damjan Lajh
doaj +1 more source