Results 71 to 80 of about 168,982,903 (290)
A distribution network is transforming into multi-area distribution networks. Traditional iterative multi-area coordination methods protect the privacy of each area but face a high communication burden and convergence issues. To address these challenges,
Ling Luo +7 more
doaj +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Open Method of Coordination in the European research policy
Research, development and innovation (R+D) are of great importance nowadays as regards the competetiveness and economic growth of any given country. In the European Union the Lisbon Strategy considers R+D as a crutial means to enhance european competetiveness.
József Mikita, János Nagy
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Evolvement of Public Open Spaces in Historical Environments of Yerevan City
In this article the role of public open spaces in Yerevan city as well as their correct and literate organisation from an architectural and planning perspective are studied and evaluated.
Mamyan Zaruhi +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Las transformaciones de las fuentes de derecho del trabajo: Una aproximación
The Spanish Labour Law system has been profoundly changed along the last three decades. These transformations have intensely and extendedly affected this system’s elements. The present article tries to offer a general perspective of those transformations,
Fernando Valdés Dal-ré
doaj
X-ray absorption near-edge structure (XANES) spectra are employed to characterise the coordination numbers of metallic elements within materials. However, conventional XANES analysis methods frequently rely on preconceived assumptions regarding the ...
Jianan Gao +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

